ArticleIntensive care medicine2008
Association between urokinase haplotypes and outcome from infection-associated acute lung injury.
Article in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Haplotype analysis of ApoAI gene and sepsis-associated acute lung injury.Lipids in health and disease · 2014Article
- Integrative assessment of chlorine-induced acute lung injury in mice.American journal of respiratory cell and molecular biology · 2012Article
- Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.PloS one · 2012Article
- Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury.BMC medical genetics · 2010Article
- Genetic polymorphisms associated with acute lung injury.Pharmacogenomics · 2009Review
- Recent advances in genetic predisposition to clinical acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2009Review
- Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation.Intensive care medicine · 2009Review
- A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury.Critical care (London, England) · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAlterations in coagulation, including elevated pulmonary and systemic concentrations of urokinase, are frequent in patients with acute lung injury (ALI). Urokinase potentiates neutrophil activation and contributes to the severity of pulmonary injury in preclinical models of ALI. The objective of this study was to examine associations between polymorphisms and haplotypes of urokinase with risk for and outcomes from ALI.
designProspective cohorts of healthy European-American adults and those with infection-associated ALI.
settingAcademic medical centers participating in NIH funded studies of low tidal volume ventilation for ALI. PATIENTS: Controls were 175 healthy European-American subjects. Patients were 252 individuals with infection-associated ALI, prospectively followed for 60 days for mortality.
interventionsGenetic polymorphisms and haplotypes in the urokinase gene were determined. MEASUREMENTS AND MAIN
resultsSix polymorphisms, rs1916341, rs2227562, rs2227564, rs2227566, rs2227571, and rs4065, defining 98% of all urokinase haplotypes, were analyzed. There were no statistically significant associations between any single urokinase polymorphism or haplotype and risk for developing ALI. In contrast, there was a statistically significant relationship between the CGCCCC haplotype and both 60-day mortality and ventilator-free days that remained present in a multivariate analysis controlling for age and sex (p=0.033 for 60-day mortality and <0.001 for ventilator-free days).
conclusionsThese results identify a specific urokinase haplotype as a genetic risk factor for higher mortality and more severe clinical outcome in patients with infection-associated ALI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.