ArticleDiabetologia2008
Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids.
Article in Diabetologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Truncated prelamin A expression in HGPS-like patients: a transcriptional study.European journal of human genetics : EJHG · 2015Article
- Novel linkage ofInternational journal of cardiology. Heart & vasculature · 2015Article
- Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases.Journal of molecular medicine (Berlin, Germany) · 2012Review
- Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people.Neurobiology of aging · 2010Article
- Diseases of the nuclear envelope.Cold Spring Harbor perspectives in biology · 2010Review
- Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.Journal of molecular medicine (Berlin, Germany) · 2010Article
- Energetics, epigenetics, mitochondrial genetics.Mitochondrion · 2010Review
- LMNA gene mutation search in Polish patients: new features of the heterozygous Arg482Gln mutation phenotype.Endocrine · 2009Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
aims/hypothesisIn the present study, we sought to examine the evidence that LMNA variants are associated with type 2 diabetes and quantitative metabolic traits in French Europid individuals.
methodsWe genotyped 24 single nucleotide polymorphisms (SNPs) spanning the LMNA gene in 3,093 case-control participants. The association between LMNA SNPs and quantitative metabolic traits was also examined in the 1,674 normoglycaemic adults who made up the control cohort.
resultsSNP rs505058, a synonymous SNP (D446D) in exon 7, showed nominal evidence of association with type 2 diabetes [p = 0.003, odds ratio (OR) 1.30 (95% CI 1.09-1.56)] in French Europids. A meta-analysis of available rs505058 genotype data from 7,819 participants provided support for a modest association of rs505058 with type 2 diabetes [p = 0.003, OR 1.19 (95% CI 1.06-1.35)]. We found no evidence (p = 0.91) that the tag SNP rs4641 is associated with type 2 diabetes. However, a meta-analysis of all available rs4641 genotype data in a total of 15,591 participants produced borderline evidence of association [p = 0.054, OR 1.05 (95% CI 1.00-1.11)]. SNP rs6669212, in the 3' untranslated region of LMNA, exhibited suggestive associations with WHR (p = 0.013), fasting serum levels of total cholesterol (p = 0.023) and triacylglycerol (p = 0.015). We emphasise that these quantitative trait associations are not corrected for multiple testing. CONCLUSIONS/
interpretationThe available data do not support a major effect of common LMNA variation on type 2 diabetes susceptibility in northern Europeans. Further large-scale studies are required to conclusively establish the extent to which LMNA variants have an impact on quantitative metabolic traits.
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