Evidence map›Paper›PMID 17994193›Full record

ArticleClinical rheumatology2008

Familial autoimmunity: maternal parent-of-origin effect in juvenile idiopathic arthritis.

Andrew Zeft, Edith S Shear, Susan D Thompson, David N Glass, Sampath Prahalad

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical rheumatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00090571 (Research Registry for Juvenile Arthritis), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00090571 completednot on this map

Research Registry for Juvenile Arthritis

TypeobservationalSponsorNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Ran1994 to 2009Enrolled200ConditionsJuvenile Rheumatoid Arthritis
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrew ZeftDivision of Immunology and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158-1289, USA.
Edith S Shear
Susan D Thompson
David N Glass
Sampath Prahalad
Cincinnati Children's Hospital Medical Center · USUniversity of Utah · US

Funding

Pediatric Rheumatology Tissue RepostoryP01AR048929 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI GROM, ALEXEI A · 2003 to 2015
$13.6M
ROLE OF ANGPTL4, AN ANGIOGENIC MEDIATOR, IN ARTHRITISP30AR047363 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI WAGNER, MICHAEL · 2001 to 2015
$9.2M
RESEARCH REGISTRY FOR JUVENILE RHEUMATOID ARTHRITIS-264942218N01AR042218 · NIAMS · CHILDREN'S HOSPITAL MED CTR (CINCINNATI) · 1994 to 2003
$778k
Genetic variation in T-cell regulatory molecules and JRAK23AR050177 · NIAMS · UNIVERSITY OF UTAH · PI PRAHALAD, SAMPATH · 2004 to 2008
$674k
NHLBI NIH HHS N01 AR042272NIAMS NIH HHS AR 42218NIAMS NIH HHS AR 42272NIAMS NIH HHS AR 47363NIAMS NIH HHS AR 50177NIAMS NIH HHS K23 AR050177NIAMS NIH HHS N01 AR042218NIAMS NIH HHS P01 AR048929NIAMS NIH HHS P30 AR047363
6 · The paper itself

Abstract

Juvenile idiopathic arthritis (JIA) is an autoimmune (AI) disease characterized by chronic arthritis in children. Children with JIA have increased prevalence of other AI diseases. Furthermore, relatives of children with JIA have been shown to have an increased prevalence of AI diseases. Our objective was to determine if there were differences in the prevalence of AI diseases among maternal and paternal relatives of children with JIA. Information about AI diseases among all living first- and second-degree relatives was collected by structured interviews with families of 121 simplex JIA families, 23 multiplex JIA families, and 45 control families. Overall, the prevalence of AI diseases was significantly increased among maternal second-degree relatives of cases compared to that of maternal second-degree relatives of controls [14% vs. 4.3%; p < 0.001]. The prevalence of AI diseases among mothers of JIA cases was three times that of fathers [32.3% vs. 11.4%; p < 0.0001]. The prevalence of AI diseases among all maternal second-degree relatives of children with JIA was significantly higher than that of all paternal second-degree relatives [14% vs. 7.9%; p < 0.004]. Although additional paternal effects cannot be excluded, together these results demonstrate that maternal relatives of children with JIA have an increased prevalence of autoimmunity compared to paternal relatives, suggesting that there might be a maternal parent-of-origin effect in JIA.

Indexed as

Genetic Predisposition to DiseasePedigreeArthritis, JuvenileAutoimmunityEpigenesis, GeneticFemaleHumansInterviews as TopicMaleMothersOdds Ratio

Identifiers

PMID17994193
PMCPMC2596926
OpenAlexW2043149332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.