Evolution of genes and genomes on the Drosophila phylogeny.
Drosophila 12 Genomes Consortium, Andrew G Clark, Michael B Eisen, Douglas R Smith, Casey M Bergman, Brian Oliver, Therese A Markow, Thomas C Kaufman, Manolis Kellis, William Gelbart and 408 more
Article in Nature, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,209 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,209citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1,209 citing papers in PubMed, 1 synthesis or guideline pooled it.
Drosophila 12 Genomes ConsortiumDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. ac347@cornell.edu
Andrew G Clark
Michael B Eisen
Douglas R Smith
Casey M Bergman
Brian Oliver
Therese A Markow
Thomas C Kaufman
Manolis Kellis
William Gelbart
Venky N Iyer
Daniel A Pollard
Timothy B Sackton
Amanda M Larracuente
Nadia D Singh
Jose P Abad
Dawn N Abt
Boris Adryan
Montserrat Aguade
Hiroshi Akashi
Wyatt W Anderson
Charles F Aquadro
David H Ardell
Roman Arguello
Carlo G Artieri
Daniel A Barbash
Daniel Barker
Paolo Barsanti
Phil Batterham
Serafim Batzoglou
Dave Begun
Arjun Bhutkar
Enrico Blanco
Stephanie A Bosak
Robert K Bradley
Adrianne D Brand
Michael R Brent
Angela N Brooks
Randall H Brown
Roger K Butlin
Corrado Caggese
Brian R Calvi
A Bernardo de Carvalho
Anat Caspi
Sergio Castrezana
Susan E Celniker
Jean L Chang
Charles Chapple
Sourav Chatterji
Asif Chinwalla
Alberto Civetta
Sandra W Clifton
Josep M Comeron
James C Costello
Jerry A Coyne
Jennifer Daub
Robert G David
Arthur L Delcher
Kim Delehaunty
Chuong B Do
Heather Ebling
Kevin Edwards
Thomas Eickbush
Jay D Evans
Alan Filipski
Sven Findeiss
Eva Freyhult
Lucinda Fulton
Robert Fulton
Ana C L Garcia
Anastasia Gardiner
David A Garfield
Barry E Garvin
Greg Gibson
Don Gilbert
Sante Gnerre
Jennifer Godfrey
Robert Good
Valer Gotea
Brenton Gravely
Anthony J Greenberg
Sam Griffiths-Jones
Samuel Gross
Roderic Guigo
Erik A Gustafson
Wilfried Haerty
Matthew W Hahn
Daniel L Halligan
Aaron L Halpern
Gillian M Halter
Mira V Han
Andreas Heger
LaDeana Hillier
Angie S Hinrichs
Ian Holmes
Roger A Hoskins
Melissa J Hubisz
Dan Hultmark
Melanie A Huntley
David B Jaffe
Santosh Jagadeeshan
William R Jeck
Justin Johnson
Corbin D Jones
William C Jordan
Gary H Karpen
Eiko Kataoka
Peter D Keightley
Pouya Kheradpour
Ewen F Kirkness
Leonardo B Koerich
Karsten Kristiansen
Dave Kudrna
Rob J Kulathinal
Sudhir Kumar
Roberta Kwok
Eric Lander
Charles H Langley
Richard Lapoint
Brian P Lazzaro
So-Jeong Lee
Lisa Levesque
Ruiqiang Li
Chiao-Feng Lin
Michael F Lin
Kerstin Lindblad-Toh
Ana Llopart
Manyuan Long
Lloyd Low
Elena Lozovsky
Jian Lu
Meizhong Luo
Carlos A Machado
Wojciech Makalowski
Mar Marzo
Muneo Matsuda
Luciano Matzkin
Bryant McAllister
Carolyn S McBride
Brendan McKernan
Kevin McKernan
Maria Mendez-Lago
Patrick Minx
Michael U Mollenhauer
Kristi Montooth
Stephen M Mount
Xu Mu
Eugene Myers
Barbara Negre
Stuart Newfeld
Rasmus Nielsen
Mohamed A F Noor
Patrick O'Grady
Lior Pachter
Montserrat Papaceit
Matthew J Parisi
Michael Parisi
Leopold Parts
Jakob S Pedersen
Graziano Pesole
Adam M Phillippy
Chris P Ponting
Mihai Pop
Damiano Porcelli
Jeffrey R Powell
Sonja Prohaska
Kim Pruitt
Marta Puig
Hadi Quesneville
Kristipati Ravi Ram
David Rand
Matthew D Rasmussen
Laura K Reed
Robert Reenan
Amy Reily
Karin A Remington
Tania T Rieger
Michael G Ritchie
Charles Robin
Yu-Hui Rogers
Claudia Rohde
Julio Rozas
Marc J Rubenfield
Alfredo Ruiz
Susan Russo
Steven L Salzberg
Alejandro Sanchez-Gracia
David J Saranga
Hajime Sato
Stephen W Schaeffer
Michael C Schatz
Todd Schlenke
Russell Schwartz
Carmen Segarra
Rama S Singh
Laura Sirot
Marina Sirota
Nicholas B Sisneros
Chris D Smith
Temple F Smith
John Spieth
Deborah E Stage
Alexander Stark
Wolfgang Stephan
Robert L Strausberg
Sebastian Strempel
David Sturgill
Granger Sutton
Granger G Sutton
Wei Tao
Sarah Teichmann
Yoshiko N Tobari
Yoshihiko Tomimura
Jason M Tsolas
Vera L S Valente
Eli Venter
J Craig Venter
Saverio Vicario
Filipe G Vieira
Albert J Vilella
Alfredo Villasante
Brian Walenz
Jun Wang
Marvin Wasserman
Thomas Watts
Derek Wilson
Richard K Wilson
Rod A Wing
Mariana F Wolfner
Alex Wong
Gane Ka-Shu Wong
Chung-I Wu
Gabriel Wu
Daisuke Yamamoto
Hsiao-Pei Yang
Shiaw-Pyng Yang
James A Yorke
Kiyohito Yoshida
Evgeny Zdobnov
Peili Zhang
Yu Zhang
Aleksey V Zimin
Jennifer Baldwin
Amr Abdouelleil
Jamal Abdulkadir
Adal Abebe
Brikti Abera
Justin Abreu
St Christophe Acer
Lynne Aftuck
Allen Alexander
Peter An
Erica Anderson
Scott Anderson
Harindra Arachi
Marc Azer
Pasang Bachantsang
Andrew Barry
Tashi Bayul
Aaron Berlin
Daniel Bessette
Toby Bloom
Jason Blye
Leonid Boguslavskiy
Claude Bonnet
Boris Boukhgalter
Imane Bourzgui
Adam Brown
Patrick Cahill
Sheridon Channer
Yama Cheshatsang
Lisa Chuda
Mieke Citroen
Alville Collymore
Patrick Cooke
Maura Costello
Katie D'Aco
Riza Daza
Georgius De Haan
Stuart DeGray
Christina DeMaso
Norbu Dhargay
Kimberly Dooley
Erin Dooley
Missole Doricent
Passang Dorje
Kunsang Dorjee
Alan Dupes
Richard Elong
Jill Falk
Abderrahim Farina
Susan Faro
Diallo Ferguson
Sheila Fisher
Chelsea D Foley
Alicia Franke
Dennis Friedrich
Loryn Gadbois
Gary Gearin
Christina R Gearin
Georgia Giannoukos
Tina Goode
Joseph Graham
Edward Grandbois
Sharleen Grewal
Kunsang Gyaltsen
Nabil Hafez
Birhane Hagos
Jennifer Hall
Charlotte Henson
Andrew Hollinger
Tracey Honan
Monika D Huard
Leanne Hughes
Brian Hurhula
M Erii Husby
Asha Kamat
Ben Kanga
Seva Kashin
Dmitry Khazanovich
Peter Kisner
Krista Lance
Marcia Lara
William Lee
Niall Lennon
Frances Letendre
Rosie LeVine
Alex Lipovsky
Xiaohong Liu
Jinlei Liu
Shangtao Liu
Tashi Lokyitsang
Yeshi Lokyitsang
Rakela Lubonja
Annie Lui
Pen MacDonald
Vasilia Magnisalis
Kebede Maru
Charles Matthews
William McCusker
Susan McDonough
Teena Mehta
James Meldrim
Louis Meneus
Oana Mihai
Atanas Mihalev
Tanya Mihova
Rachel Mittelman
Valentine Mlenga
Anna Montmayeur
Leonidas Mulrain
Adam Navidi
Jerome Naylor
Tamrat Negash
Thu Nguyen
Nga Nguyen
Robert Nicol
Choe Norbu
Nyima Norbu
Nathaniel Novod
Barry O'Neill
Sahal Osman
Eva Markiewicz
Otero L Oyono
Christopher Patti
Pema Phunkhang
Fritz Pierre
Margaret Priest
Sujaa Raghuraman
Filip Rege
Rebecca Reyes
Cecil Rise
Peter Rogov
Keenan Ross
Elizabeth Ryan
Sampath Settipalli
Terry Shea
Ngawang Sherpa
Lu Shi
Diana Shih
Todd Sparrow
Jessica Spaulding
John Stalker
Nicole Stange-Thomann
Sharon Stavropoulos
Catherine Stone
Christopher Strader
Senait Tesfaye
Talene Thomson
Yama Thoulutsang
Dawa Thoulutsang
Kerri Topham
Ira Topping
Tsamla Tsamla
Helen Vassiliev
Andy Vo
Tsering Wangchuk
Tsering Wangdi
Michael Weiand
Jane Wilkinson
Adam Wilson
Shailendra Yadav
Geneva Young
Qing Yu
Lisa Zembek
Danni Zhong
Andrew Zimmer
Zac Zwirko
David B Jaffe
Pablo Alvarez
Will Brockman
Jonathan Butler
CheeWhye Chin
Sante Gnerre
Manfred Grabherr
Michael Kleber
Evan Mauceli
Iain MacCallum
Funding
POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
The Drosophila Heterochromatin Genome ProjectR01HG000747 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KARPEN, GARY H · 1992 to 2008
$9.3M
COMPUTATIONAL MODELING OF GENES AND GENE STRUCTURER01LM006845 · NLM · UNIV OF MARYLAND, COLLEGE PARK · PI SALZBERG, STEVEN L. · 1999 to 2010
$5.9M
ACTIONS OF SEMINAL PROTEINS IN MATED DROSOPHILA FEMALESR01HD038921 · NICHD · CORNELL UNIVERSITY ITHACA · PI WOLFNER, MARIANA FEDERICA · 2000 to 2019
$5.6M
Modeling the Evolution and Function of Drosophila cis-Regulatory ModulesR01HG002779 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI EISEN, MICHAEL BRUCE · 2003 to 2012
$5.3M
Regulatory Morif Discovery in the Human Genome Using Comparative GenomicsR01HG004037 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS · 2007 to 2015
$3.9M
MOLECULAR POPULATION GENETICS OF DROSOPHILA MELANOGASTERR01GM036431 · NIGMS · CORNELL UNIVERSITY ITHACA · PI AQUADRO, CHARLES F · 1986 to 2010
$2.6M
Functional Dynamics and Molecular Mechanism of PhotolayseR01GM074813 · NIGMS · OHIO STATE UNIVERSITY · PI ZHONG, DONGPING · 2007 to 2016
$2.6M
GERMLINE SEX DETERMINATIONZ01DK015600 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI OLIVER, BRIAN C · 1996 to 2008
$949k
Immunity to a Parasitoid Wasp in Drosophila melanogasterF32GM067504 · NIGMS · CORNELL UNIVERSITY ITHACA · PI SCHLENKE, TODD ALEXANDER · 2003 to 2005
$132k
Biotechnology and Biological Sciences Research Council BB/D015480/1Intramural NIH HHS Z01 DK015600Medical Research Council MC_U105161047Medical Research Council MC_U137761446NHGRI NIH HHS R01 HG000747NHGRI NIH HHS R01 HG002779NHGRI NIH HHS R01 HG004037NICHD NIH HHS R01 HD038921NIGMS NIH HHS F32 GM067504NIGMS NIH HHS R01 GM036431NIGMS NIH HHS R01 GM074813NLM NIH HHS R01 LM006845NLM NIH HHS T15 LM007033
6 · The paper itself
Abstract
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Evolution of genes and genomes on the Drosophila phylogeny. · full record | OpenQuestion