ArticleJournal of veterinary science2007
Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings.
Article in Journal of veterinary science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Animal stroke models and outcome evaluation: A review.Animal models and experimental medicine · 2026Review
- Review
- QSM in canine model of acute cerebral ischemia: A pilot study.Magnetic resonance in medicine · 2021Article
- Large animal ischemic stroke models: replicating human stroke pathophysiology.Neural regeneration research · 2020Review
- Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion.Translational stroke research · 2020Article
- Temporal Evolution of MRI Characteristics in Dogs with Collagenase-Induced Intracerebral Hemorrhage.Comparative medicine · 2015Article
- Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical features, magnetic resonance imaging, histopathology, and immunohistochemistry.Journal of veterinary science · 2015Article
- Comparative study of the relative signal intensity on DWI, FLAIR, and T2 images in identifying the onset time of stroke in an embolic canine model.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- Experimental models of brain ischemia: a review of techniques, magnetic resonance imaging, and investigational cell-based therapies.Frontiers in neurology · 2014Review
- Preliminary investigation of the dissolution behavior, cytocompatibility, effects of fibrinogen conformation and platelet adhesion for radiopaque embolic particles.Journal of functional biomaterials · 2013Article
- Application of sodium alginate microspheres in ischemic stroke modeling in miniature pigs.Neural regeneration research · 2013Article
- In vivo MR imaging of intraarterially delivered magnetically labeled mesenchymal stem cells in a canine stroke model.PloS one · 2013Article
- Histopathological Investigation of Different MCAO Modalities and Impact of Autologous Bone Marrow Mononuclear Cell Administration in an Ovine Stroke Model.Translational stroke research · 2011Article
- MRI features in a canine model of ischemic stroke: correlation between lesion volume and neurobehavioral status during the subacute stage.Comparative medicine · 2009Article
- Three-dimensional time-of-flight magnetic resonance angiography of intracranial vessels in a canine model of ischemic stroke with permanent occlusion of the middle cerebral artery.Comparative medicine · 2009Article
- Selection of preclinical models to evaluate intranasal brain cooling for acute ischemic stroke.Brain circulationReview
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery occlusion in four healthy beagle dogs using silicone plugs. They showed neurological signs of forebrain dysfunction such as reduced responsiveness, head turning, circling, postural reaction deficits, perceptual deficits, and hemianopsia. These signs gradually regressed within 4 weeks without therapy. On magnetic resonance imaging, T2 hyperintensity and T1 hypointensity were found in the cerebral cortex and basal ganglia. These lesions were well-defined and sharply demarcated from adjacent brain parenchyma with a homogenous appearance. No abnormalities of the cerebrospinal fluid were observed. At necropsy, atrophic and necrotic lesions were observed in the cerebral cortex. The cerebral cortex, basal ganglia, and thalamus were partially unstained with triphenyl- tetrazolium chloride. Histopathologically, typical features of infarction were identified in cortical and thalamic lesions. This study demonstrates that our canine model resembles the conditions of real stroke patients.
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