ArticleCancer genomics & proteomics
Differential expression of ribosomal proteins in a human metastasis model identified by coupling 2-D liquid chromatography and mass spectrometry.
Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Mass Spectrometry-Based Proteomics of Human Milk to Identify Differentially Expressed Proteins in Women with Breast Cancer versus Controls.Proteomes · 2022Article
- Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction.Journal of food and drug analysis · 2018Article
- Down-regulation of RPS9 Inhibits Osteosarcoma Cell Growth through Inactivation of MAPK Signaling Pathway.Journal of Cancer · 2017Article
- Determining protein biomarkers for DLBCL using FFPE tissues from HIV negative and HIV positive patients.Journal of molecular histology · 2016Article
- NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.Molecular & cellular proteomics : MCP · 2015Article
- Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications.Medicinal research reviews · 2015Review
- Urinary glycoprotein biomarker discovery for bladder cancer detection using LC/MS-MS and label-free quantification.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Urinary proteomic profiling for diagnostic bladder cancer biomarkers.Expert review of proteomics · 2009Review
- Urine-based assays for the detection of bladder cancer.Biomarkers in medicine · 2009Article
- Breast tumor metastasis: analysis via proteomic profiling.Expert review of proteomics · 2008Review
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundProteomic profiling of an experimental tumor metastasis model has the potential to identify gene products that can influence this fatal phenotype of tumor cells. In this study, we focused on the notoriously difficult to assess ribosomal protein component of a pair of cell lines which originate from the same tumor but have opposite metastatic capabilities. MATERIALS AND
methodsCell lysate proteins were separated using a two-dimensional liquid chromatographic system directly coupled to an ESI-TOF mass spectrometer for accurate intact protein MW analysis. Characterization of distinct post-translational modifications and sequence variation within several ribosomal proteins was obtained using monolithic capillary LC/MS/MS, MALDI-MS and -MS/MS.
resultsThe combination of these techniques enabled the identification of 45 unique ribosomal proteins, several of which were differentially expressed in metastatic M4A4 cells.
conclusionThe described proteomic profiling approach enables the identification of phenotype-associated ribosomal proteins for subsequent functional analyses and disease biomarker development.
Indexed as
Identifiers
17993717PMC3426217W2187969232What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.