ArticleThe Plant cell2007
Nitrate efflux at the root plasma membrane: identification of an Arabidopsis excretion transporter.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 201 citations in OpenAlex.
- The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition.The New phytologist · 2026Article
- An omnigenic interactome model to chart the genetic architecture of individual plants.Horticulture research · 2026Article
- Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack.The New phytologist · 2026Review
- Characterization ofFrontiers in plant science · 2026Article
- PcNPF2.7 from the XerophyteBiology · 2025Article
- Genome-Wide Identification and Expression Analysis of PkNRT Gene Family in Korean Pine (Plants (Basel, Switzerland) · 2025Article
- Review
- Genome-Wide Identification and Expression Analysis ofPlants (Basel, Switzerland) · 2023Article
- Responses of roots and rhizosphere of female papaya to the exogenous application of GABMC plant biology · 2023Article
- Enhancing crop yields through improvements in the efficiency of photosynthesis and respiration.The New phytologist · 2023Review
- Alkalinity modulates a unique suite of genes to recalibrate growth and pH homeostasis.Frontiers in plant science · 2023Article
- Unlocking the potentials of nitrate transporters at improving plant nitrogen use efficiency.Frontiers in plant science · 2023Review
- Genome-Wide Identification and Expression Analysis ofInternational journal of molecular sciences · 2022Article
- The Roles of Phosphorus and Nitrogen Nutrient Transporters in the Arbuscular Mycorrhizal Symbiosis.International journal of molecular sciences · 2022Review
- Root nitrate uptake in sugarcane (Saccharum spp.) is modulated by transcriptional and presumably posttranscriptional regulation of the NRT2.1/NRT3.1 transport system.Molecular genetics and genomics : MGG · 2022Article
- Phylogeny and Expression Atlas of thePlants (Basel, Switzerland) · 2022Article
- Enhancement of nitrogen use efficiency through agronomic and molecular based approaches in cotton.Frontiers in plant science · 2022Review
- Transcriptome profiling shows a rapid variety-specific response in two Andigenum potato varieties under drought stress.Frontiers in plant science · 2022Article
- Genome-wide identification and characterization of the NPF genes provide new insight into low nitrogen tolerance inFrontiers in plant science · 2022Article
- Root-Specific Expression ofFrontiers in plant science · 2022Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root NO(3)(-) efflux to the outer medium is a component of NO(3)(-) net uptake and can even overcome influx upon various stresses. Its role and molecular basis are unknown. Following a functional biochemical approach, NAXT1 (for NITRATE EXCRETION TRANSPORTER1) was identified by mass spectrometry in the plasma membrane (PM) of Arabidopsis thaliana suspension cells, a localization confirmed using a NAXT1-Green Fluorescent Protein fusion protein. NAXT1 belongs to a subclass of seven NAXT members from the large NITRATE TRANSPORTER1/PEPTIDE TRANSPORTER family and is mainly expressed in the cortex of mature roots. The passive NO(3)(-) transport activity (K(m) = 5 mM) in isolated root PM, electrically coupled to the ATP-dependant H(+)-pumping activity, is inhibited by anti-NAXT antibodies. In standard culture conditions, NO(3)(-) contents were altered in plants expressing NAXT-interfering RNAs but not in naxt1 mutant plants. Upon acid load, unidirectional root NO(3)(-) efflux markedly increased in wild-type plants, leading to a prolonged NO(3)(-) excretion regime concomitant with a decrease in root NO(3)(-) content. In vivo and in vitro mutant phenotypes revealed that this response is mediated by NAXT1, whose expression is upregulated at the posttranscriptional level. Strong medium acidification generated a similar response. In vitro, the passive efflux of NO(3)(-) (but not of Cl(-)) was strongly impaired in naxt1 mutant PM. This identification of NO(3)(-) efflux transporters at the PM of plant cells opens the way to molecular studies of the physiological role of NO(3)(-) efflux in stressed or unstressed plants.
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