ArticleThe Plant cell2007
SAD2, an importin -like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear trafficking.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 189 citations in OpenAlex.
- Genome-Wide Study of MYB Transcription Factors in Maize and Their Essential Roles in Male Fertility and Other Biological Processes.International journal of molecular sciences · 2026Article
- The Long Intergenic Noncoding RNAPlants (Basel, Switzerland) · 2026Article
- Engineering 2-Pyrone-4,6-Dicarboxylic Acid Production Reveals Metabolic Plasticity of Poplar.Plant biotechnology journal · 2026Article
- Exploring candidate genes related to pollen abortion in garlic (Allium sativum) based on cytological studies and transcriptome sequencing.Journal of plant research · 2025Article
- Environmental gradients shape genetic variation in the desert moss, Syntrichia caninervis Mitt. (Pottiaceae).Scientific reports · 2025Article
- Bio-organic fertilizer affects secondary cell wall biosynthesis of Dendrocalamus farinosus by inhibiting the phenylpropanoid metabolic pathway.BMC plant biology · 2024Article
- Article
- Molecular mechanism analysis of ZmRL6 positively regulating drought stress tolerance in maize.Stress biology · 2023Article
- The MYB transcription factor RcMYB1 plays a central role in rose anthocyanin biosynthesis.Horticulture research · 2023Article
- Natural variation in Beauty Mark is associated with UV-based geographical adaptation in Gossypium species.BMC biology · 2023Article
- Abscisic Acid Inhibits Cortical Microtubules Reorganization and Enhances Ultraviolet-B Tolerance inGenes · 2023Article
- Genome-wide characterization and expression analysis of MYB transcription factors in Chrysanthemum nankingense.BMC plant biology · 2023Article
- Transcriptomic Analysis Revealed Key Defense Genes and Signaling Pathways Mediated by theInternational journal of molecular sciences · 2023Article
- Genome-wide analysis of R2R3-MYB transcription factors inFrontiers in genetics · 2023Article
- Identification of the Karyopherin Superfamily in Maize and Its Functional Cues in Plant Development.International journal of molecular sciences · 2022Review
- Transcription factor CmbHLH16 regulates petal anthocyanin homeostasis under different lights in Chrysanthemum.Plant physiology · 2022Article
- Multi-omic characterization of bifunctional peroxidase 4-coumarate 3-hydroxylase knockdown inFrontiers in plant science · 2022Article
- An Importin-β-like Protein fromViruses · 2021Article
- SWO1 modulates cell wall integrity under salt stress by interacting with importin ɑ in Arabidopsis.Stress biology · 2021Article
- Effects of Light Intensity and Spectral Composition on the Transcriptome Profiles of Leaves in Shade Grown Tea Plants (Molecules (Basel, Switzerland) · 2021Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report that the Arabidopsis thaliana mutant sensitive to ABA and drought2 (sad2), which harbors a T-DNA insertion in an importin beta-like gene, is more tolerant to UV-B radiation than the wild type. Analysis of cyclobutane pyrimidine dimer accumulation revealed that less DNA damage occurred in sad2 than in the wild type during UV-B treatment. No significant growth difference was observed between sad2 and the wild type when treated with the genotoxic drug methyl methanesulfonate, suggesting that SAD2 functions in UV-B protection rather than in DNA damage repair. Whereas the R2R3-type transcription repressor MYB4 has previously been shown to negatively regulate the transcription of cinnamate 4-hydroxylase (C4H) and thus to regulate the synthesis of sinapate esters, expression of both MYB4 and C4H and accumulation of UV-absorbing compounds were significantly higher in sad2 than in the wild type. MYB4 did not localize to the nucleus in the sad2 mutant, suggesting that SAD2 is required for MYB4 nuclear trafficking. SAD2 and MYB4 coimmunoprecipitated, indicating that these proteins localize in the same complex in vivo. MYB4 protein specifically bound to its own promoter in gel shift assays and repressed its own expression, demonstrating that MYB4 protein and mRNA are part of a negative autoregulatory loop. This feedback loop is altered in the sad2 mutant due to the absence of MYB4 protein in the nucleus, leading to the constitutive expression of MYB4 and C4H and resulting in accumulation of UV-absorbing pigments that shield the plant from UV-B radiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.