ArticleEukaryotic cell2008
Responses of pathogenic and nonpathogenic yeast species to steroids reveal the functioning and evolution of multidrug resistance transcriptional networks.
Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Transcriptomic studies on the product stress response revealed that YCF1 is a beneficial factor for progesterone production inSynthetic and systems biotechnology · 2025Article
- Sub-Therapeutic Concentrations of Hexetidine Induce Virulence Gene Expression inInfection and drug resistance · 2025Article
- Functional and transcriptional profiling of non-coding RNAs in yeast reveal context-dependent phenotypes and in trans effects on the protein regulatory network.PLoS genetics · 2021Article
- Zinc Oxide Nanoparticles Inhibition of Initial Adhesion and ALS1 and ALS3 Gene Expression in Candida albicans Strains from Urinary Tract Infections.Mycopathologia · 2019Article
- Commonly Used Oncology Drugs Decrease Antifungal Effectiveness against Candida and Aspergillus Species.Antimicrobial agents and chemotherapy · 2018Article
- Control of Plasma Membrane Permeability by ABC Transporters.Eukaryotic cell · 2015Article
- Yeast ABC proteins involved in multidrug resistance.Cellular & molecular biology letters · 2014Review
- Curcumin targets cell wall integrity via calcineurin-mediated signaling in Candida albicans.Antimicrobial agents and chemotherapy · 2014Article
- Multidrug resistance in fungi: regulation of transporter-encoding gene expression.Frontiers in physiology · 2014Review
- Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans.International journal of microbiology · 2013Review
- RNA sequencing revealed novel actors of the acquisition of drug resistance in Candida albicans.BMC genomics · 2012Article
- Lipidome analysis reveals antifungal polyphenol curcumin affects membrane lipid homeostasis.Frontiers in bioscience (Elite edition) · 2012Article
- In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2.Antimicrobial agents and chemotherapy · 2012Article
- Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans.PloS one · 2011Article
- Statistical inference of the time-varying structure of gene-regulation networks.BMC systems biology · 2010Article
- Inference of sparse combinatorial-control networks from gene-expression data: a message passing approach.BMC bioinformatics · 2010Article
- Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering.Genome biology · 2010Article
- Efflux-mediated antifungal drug resistance.Clinical microbiology reviews · 2009Review
- Structure and properties of transcriptional networks driving selenite stress response in yeasts.BMC genomics · 2008Article
- Genome adaptation to chemical stress: clues from comparative transcriptomics in Saccharomyces cerevisiae and Candida glabrata.Genome biology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Steroids are known to induce pleiotropic drug resistance states in hemiascomycetes, with tremendous potential consequences for human fungal infections. Our analysis of gene expression in Saccharomyces cerevisiae and Candida albicans cells subjected to three different concentrations of progesterone revealed that their pleiotropic drug resistance (PDR) networks were strikingly sensitive to steroids. In S. cerevisiae, 20 of the Pdr1p/Pdr3p target genes, including PDR3 itself, were rapidly induced by progesterone, which mimics the effects of PDR1 gain-of-function alleles. This unique property allowed us to decipher the respective roles of Pdr1p and Pdr3p in PDR induction and to define functional modules among their target genes. Although the expression profiles of the major PDR transporters encoding genes ScPDR5 and CaCDR1 were similar, the S. cerevisiae global PDR response to progesterone was only partly conserved in C. albicans. In particular, the role of Tac1p, the main C. albicans PDR regulator, in the progesterone response was apparently restricted to five genes. These results suggest that the C. albicans and S. cerevisiae PDR networks, although sharing a conserved core regarding the regulation of membrane properties, have different structures and properties. Additionally, our data indicate that other as yet undiscovered regulators may second Tac1p in the C. albicans drug response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.