Evidence map›Paper›PMID 17993570›Full record

ArticleEukaryotic cell2007

Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis.

Libera Lo Presti, Moira Cockell, Lorenzo Cerutti, Viesturs Simanis, Philippe M Hauser

Open access · diamondAbstract read
In one paragraph

Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Genome-Wide Transcriptional Changes ofFrontiers in microbiology · 2021
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Pneumocystis.Cold Spring Harbor perspectives in medicine · 2014
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Libera Lo PrestiInstitute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland.
Moira Cockell
Lorenzo Cerutti
Viesturs Simanis
Philippe M Hauser
University of Lausanne · CHÉcole Polytechnique Fédérale de Lausanne · CHSIB Swiss Institute of Bioinformatics · CHUniversity Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immunocompromised humans. The brl1 gene of P. carinii infecting rats was identified and characterized by using bioinformatics in conjunction with functional complementation in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the Brr6/Brl1 family in both yeasts.

Indexed as

Gene Expression Regulation, FungalGenetic Complementation TestAllelesAmino Acid SequenceAnimalsComputational BiologyMembrane ProteinsMolecular Sequence DataNuclear ProteinsPneumocystis cariniiRatsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSchizosaccharomycesSequence Homology, Amino AcidSpecies SpecificityBrr6 protein, S cerevisiaeMembrane ProteinsNuclear ProteinsSaccharomyces cerevisiae Proteins

Identifiers

PMID17993570
PMCPMC2168235
OpenAlexW2124695543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.