ArticleApplied and environmental microbiology2008
Cloning and characterization of two Lactobacillus casei genes encoding a cystathionine lyase.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Cysteine-S-conjugate β-lyase: a green catalyst for the production of flavor-active mercaptoketones.Applied microbiology and biotechnology · 2026Article
- Underground isoleucine biosynthesis pathways ineLife · 2020Article
- Transcriptional Regulation of Cysteine and Methionine Metabolism inFrontiers in microbiology · 2018Article
- A Novel Bifunctional Amino Acid Racemase With Multiple Substrate Specificity, MalY FromFrontiers in microbiology · 2018Article
- Structural Snapshots of an Engineered Cystathionine-γ-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.Biochemistry · 2017Article
- A Perspective Study of Koumiss Microbiome by Metagenomics Analysis Based on Single-Cell Amplification Technique.Frontiers in microbiology · 2017Article
- Cysteine biosynthesis in Lactobacillus casei: identification and characterization of a serine acetyltransferase.FEMS microbiology letters · 2016Article
- The Impact of Proteolytic Pork Hydrolysate on Microbial, Flavor and Free Amino Acids Compounds of Yogurt.Korean journal for food science of animal resources · 2016Article
- Transcriptional and Proteomic Profiling of Aspergillus flavipes in Response to Sulfur Starvation.PloS one · 2015Article
- Computational analysis of cysteine and methionine metabolism and its regulation in dairy starter and related bacteria.Journal of bacteriology · 2012Article
- Microbial pathways in colonic sulfur metabolism and links with health and disease.Frontiers in physiology · 2012Article
- Engineering Saccharomyces cerevisiae to release 3-Mercaptohexan-1-ol during fermentation through overexpression of an S. cerevisiae Gene, STR3, for improvement of wine aroma.Applied and environmental microbiology · 2011Article
- In Helicobacter pylori, LuxS is a key enzyme in cysteine provision through a reverse transsulfuration pathway.Journal of bacteriology · 2010Article
- Cystathionine gamma-lyase is a component of cystine-mediated oxidative defense in Lactobacillus reuteri BR11.Journal of bacteriology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Volatile sulfur compounds are key flavor compounds in several cheese types. To better understand the metabolism of sulfur-containing amino acids, which certainly plays a key role in the release of volatile sulfur compounds, we searched the genome database of Lactobacillus casei ATCC 334 for genes encoding putative homologs of enzymes known to degrade cysteine, cystathionine, and methionine. The search revealed that L. casei possesses two genes that putatively encode a cystathionine beta-lyase (CBL; EC 4.4.1.8). The enzyme has been implicated in the degradation of not only cystathionine but also cysteine and methionine. Recombinant CBL proteins catalyzed the degradation of L-cystathionine, O-succinyl-L-homoserine, L-cysteine, L-serine, and L-methionine to form alpha-keto acid, hydrogen sulfide, or methanethiol. The two enzymes showed notable differences in substrate specificity and pH optimum.
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