ArticleJournal of bacteriology2008
Genome sequence of Lactobacillus helveticus, an organism distinguished by selective gene loss and insertion sequence element expansion.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82 citing papers in PubMed.
- Limits to the evolution of metabolic dependency in spatially structured microbial communities.iScience · 2026Article
- Safety Assessment of GABA-Producing Levilactobacillus brevis LAB6 MTCC 25662 and Its Anti-inflammatory Effects in Murine Macrophages.Probiotics and antimicrobial proteins · 2026Article
- The Capacities of the Probiotic StrainsBiomolecules · 2025Article
- The mobilome ofMicrobial genomics · 2023Article
- Reduction, evolutionary pattern and positive selection of genes encoding formate dehydrogenase in Wood-Ljungdahl pathway of gastrointestinal acetogens suggests their adaptation to formate-rich habitats.Environmental microbiology reports · 2023Article
- The Enzyme Gene Expression of Protein Utilization and Metabolism byMicroorganisms · 2022Article
- Metagenomic Insights into Chicken Gut Antibiotic Resistomes and Microbiomes.Microbiology spectrum · 2022Article
- Phenotype testing, genome analysis, and metabolic interactions of three lactic acid bacteria strains existing as a consortium in a naturally fermented milk.Frontiers in microbiology · 2022Article
- Niche-specific adaptation ofMicrobial genomics · 2021Article
- Whole-Genome Sequencing ofMicroorganisms · 2020Article
- Genomic Comparison ofFrontiers in microbiology · 2019Article
- ThemSphere · 2018Article
- Bacterial Diversity in Traditional Doogh in Comparison to Industrial Doogh.Current microbiology · 2018Article
- Complete Genome Sequences of the Probiotic Lactic Acid BacteriaGenome announcements · 2018Article
- Draft Genome Sequence ofGenome announcements · 2018Article
- Isolation and characterization of a new fructophilicAnnals of microbiology · 2018Article
- Comparative Genomics of Completely SequencedFrontiers in microbiology · 2018Article
- Unleashing Natural Competence in Lactococcus lactis by Induction of the Competence Regulator ComX.Applied and environmental microbiology · 2017Article
- Safety Assessment of Lactobacillus helveticus KLDS1.8701 Based on Whole Genome Sequencing and Oral Toxicity Studies.Toxins · 2017Article
- YebC, a putative transcriptional factor involved in the regulation of the proteolytic system of Lactobacillus.Scientific reports · 2017Article
22 more citing papers are in PubMed but not listed here.
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11 authors.
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Abstract
Mobile genetic elements are major contributing factors to the generation of genetic diversity in prokaryotic organisms. For example, insertion sequence (IS) elements have been shown to specifically contribute to niche adaptation by promoting a variety of genetic rearrangements. The complete genome sequence of the cheese culture Lactobacillus helveticus DPC 4571 was determined and revealed significant conservation compared to three nondairy gut lactobacilli. Despite originating from significantly different environments, 65 to 75% of the genes were conserved between the commensal and dairy lactobacilli, which allowed key niche-specific gene sets to be described. However, the primary distinguishing feature was 213 IS elements in the DPC 4571 genome, 10 times more than for the other lactobacilli. Moreover, genome alignments revealed an unprecedented level of genome stability between these four Lactobacillus species, considering the number of IS elements in the L. helveticus genome. Comparative analysis also indicated that the IS elements were not the primary agents of niche adaptation for the L. helveticus genome. A clear bias toward the loss of genes reported to be important for gut colonization was observed for the cheese culture, but there was no clear evidence of IS-associated gene deletion and decay for the majority of genes lost. Furthermore, an extraordinary level of sequence diversity exists between copies of certain IS elements in the DPC 4571 genome, indicating they may represent an ancient component of the L. helveticus genome. These data suggest a special unobtrusive relationship between the DPC 4571 genome and its mobile DNA complement.
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