ArticleJournal of bacteriology2008
Novel protein antigen (JHP940) from the genomic plasticity region of Helicobacter pylori induces tumor necrosis factor alpha and interleukin-8 secretion by human macrophages.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Potential pathogenesis ofFuture science OA · 2026Article
- From Primary Data to Ethnopharmacological Investigations onPlants (Basel, Switzerland) · 2024Article
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- The role of integrating conjugative elements in Helicobacter pylori: a review.Journal of biomedical science · 2018Review
- Phylogeographic diversity and mosaicism of theMobile DNA · 2018Article
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- Role of Plasticity Region Genes and cagE gene of cagPAI of Helicobacter pylori in Development of Gastrointestinal (GI) DiseasesAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Helicobacter pylori plasticity region genes are associated with the gastroduodenal diseases manifestation in India.Gut pathogens · 2016Article
- The distribution of jhp0940, jhp0945, jhp0947, jhp0949 and jhp0951 genes of Helicobacter pylori in China.BMC gastroenterology · 2015Article
- Comparative genomic analysis of Helicobacter pylori from Malaysia identifies three distinct lineages suggestive of differential evolution.Nucleic acids research · 2015Article
- Article
- Role of Helicobacter pylori plasticity region genes in development of gastroduodenal diseases.Journal of clinical microbiology · 2012Article
- Concurrent proinflammatory and apoptotic activity of a Helicobacter pylori protein (HP986) points to its role in chronic persistence.PloS one · 2011Article
- Helicobacter pylori proinflammatory protein up-regulates NF-kappaB as a cell-translocating Ser/Thr kinase.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Helicobacter pylori--a seasoned pathogen by any other name.Gut pathogens · 2009Article
- A comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori.PloS one · 2009Article
- Article
- A flood of microbial genomes-do we need more?PloS one · 2009Article
- Differences in genome content among Helicobacter pylori isolates from patients with gastritis, duodenal ulcer, or gastric cancer reveal novel disease-associated genes.Infection and immunity · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The plasticity region of the Helicobacter pylori genome comprises strain-specific gene loci. We performed genotyping and functional biology analysis of one such locus (jhp940) that was previously found to be functionally unknown but present in gastric cancer-associated strains from many different countries. We found its geographic prevalence to be independent of cagA presence and disease status. Cloning, expression, and purification of JHP940 revealed a novel, approximately 36-kDa protein in a biologically active form which elicited strong and significant levels of tumor necrosis factor alpha and interleukin-8 in human macrophages. Also, JHP940 was able to induce enhanced translocation of the transcription factor NF-kappaB complex in cultured macrophages. The induction of the proinflammatory cytokines by JHP940, therefore, points to its putative role in chronic gastric inflammation and, possibly, the various other outcomes of H. pylori infection, including gastric cancer.
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