ArticleBiophysical journal2008
Microscopic simulation of membrane molecule diffusion on corralled membrane surfaces.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Measurement of Protein Transport in Heterogeneous Environments Using Confinement k-Space Image Correlation Spectroscopy.Biomolecules · 2026Article
- Simulation Studies of Dynamical Heterogeneity in a Dense Two-Dimensional Dimer-Solvent System with Obstacles.Entropy (Basel, Switzerland) · 2024Article
- Implications of different membrane compartmentalization models in particle-basedRoyal Society open science · 2023Article
- Motion in a crowded environment: the influence of obstacles' size and shape and model of transport.Journal of molecular modeling · 2019Article
- Membrane microdomains emergence through non-homogeneous diffusion.BMC biophysics · 2012Article
- Correlating anomalous diffusion with lipid bilayer membrane structure using single molecule tracking and atomic force microscopy.The Journal of chemical physics · 2011Article
- Monte Carlo simulations of plasma membrane corral-induced EGFR clustering.Journal of biotechnology · 2011Article
- Monte Carlo investigation of diffusion of receptors and ligands that bind across opposing surfaces.Annals of biomedical engineering · 2011Article
- Quantitative understanding of cell signaling: the importance of membrane organization.Current opinion in biotechnology · 2010Review
- Adaptive coarse-grained Monte Carlo simulation of reaction and diffusion dynamics in heterogeneous plasma membranes.BMC bioinformatics · 2010Article
- Spatially distributed cell signalling.FEBS letters · 2009Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current understanding of how receptors diffuse and cluster in the plasma membrane is limited. Data from single-particle tracking and laser tweezer experiments have suggested that membrane molecule diffusion is affected by the presence of barriers dividing the membrane into corrals. Here, we have developed a stochastic spatial model to simulate the effect of corrals on the diffusion of molecules in the plasma membrane. The results of this simulation confirm that a fence barrier (the ratio of the transition probability for diffusion across a boundary to that within a corral) on the order of 10(3)-10(4) recreates the experimentally measured difference in diffusivity between artificial and natural plasma membranes. An expression for the macroscopic diffusivity of receptors on corralled membranes is derived to analyze the effects of the corral parameters on diffusion rate. We also examine whether the lattice model is an appropriate description of the plasma membrane and look at three different sets of boundary conditions that describe diffusion over the barriers and whether diffusion events on the plasma membrane may occur with a physically relevant length scale. Finally, we show that to observe anomalous (two-timescale) diffusion, one needs high temporal (microsecond) resolution along with sufficiently long (more than milliseconds) trajectories.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.