ArticleBiophysical journal2008
Evaluating intramural virtual electrodes in the myocardial wedge preparation: simulations of experimental conditions.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Electrical Stimulation for Low-Energy Termination of Cardiac Arrhythmias: a Review.Cardiovascular drugs and therapy · 2023Review
- Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.Progress in biophysics and molecular biology · 2016Review
- Cardiac response to low-energy field pacing challenges the standard theory of defibrillation.Circulation. Arrhythmia and electrophysiology · 2015Article
- Three-dimensional histology: tools and application to quantitative assessment of cell-type distribution in rabbit heart.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2014Article
- New insights into defibrillation of the heart from realistic simulation studies.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2014Review
- An efficient finite element approach for modeling fibrotic clefts in the heart.IEEE transactions on bio-medical engineering · 2014Article
- On boundary stimulation and optimal boundary control of the bidomain equations.Mathematical biosciences · 2013Article
- Computational modeling of the human atrial anatomy and electrophysiology.Medical & biological engineering & computing · 2012Review
- Representing cardiac bidomain bath-loading effects by an augmented monodomain approach: application to complex ventricular models.IEEE transactions on bio-medical engineering · 2011Article
- Probing field-induced tissue polarization using transillumination fluorescent imaging.Biophysical journal · 2010Article
- Modeling the role of the coronary vasculature during external field stimulation.IEEE transactions on bio-medical engineering · 2010Article
- Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function.American journal of physiology. Heart and circulatory physiology · 2010Article
- Article
- Generation of histo-anatomically representative models of the individual heart: tools and application.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2009Article
- Polarity reversal lowers activation time during diastolic field stimulation of the rabbit ventricles: insights into mechanisms.American journal of physiology. Heart and circulatory physiology · 2008Article
- From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
While defibrillation is the only means for prevention of sudden cardiac death, key aspects of the process, such as the intramural virtual electrodes (VEs), remain controversial. Experimental studies had attempted to assess intramural VEs by using wedge preparations and recording activity from the cut surface; however, applicability of this approach remains unclear. These studies found, surprisingly, that for strong shocks, the entire cut surface was negatively polarized, regardless of boundary conditions. The goal of this study is to examine, by means of bidomain simulations, whether VEs on the cut surface represent a good approximation to VEs in depth of the intact wall. Furthermore, we aim to explore mechanisms that could give rise to negative polarization on the cut surface. A model of wedge preparation was used, in which fiber orientation could be changed, and where the cut surface was subjected to permeable and impermeable boundary conditions. Small-scale mechanisms for polarization were also considered. To determine whether any distortions in the recorded VEs arise from averaging during optical mapping, a model of fluorescent recording was employed. The results indicate that, when an applied field is spatially uniform and impermeable boundary conditions are enforced, regardless of the fiber orientation VEs on the cut surface faithfully represent those intramurally, provided tissue properties are not altered by dissection. Results also demonstrate that VEs are sensitive to the conductive layer thickness above the cut surface. Finally, averaging during fluorescent recordings results in large negative VEs on the cut surface, but these do not arise from small-scale heterogeneities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.