ArticleIntensive care medicine2008
C-reactive protein concentration as a predictor of in-hospital mortality after ICU discharge: a prospective cohort study.
Article in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Out-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review and meta-analysis.Intensive care medicine · 2018Pooled it
- A meta-analysis to derive literature-based benchmarks for readmission and hospital mortality after patient discharge from intensive care.Critical care (London, England) · 2014Pooled it
- Usefulness of N-terminal pro-brain natriuretic peptide and C-reactive protein to predict ICU mortality in unselected medical ICU patients: a prospective, observational study.Critical care (London, England) · 2011Trial
- C-reactive protein-triglyceride glucose index and its dynamic trajectories on all-cause mortality in critically ill children: a longitudinal, retrospective cohort study.Pediatric research · 2026Article
- Prognostic Value of Maximal and Mean Lactate-to-Albumin (LAR), C-Reactive Protein-to-Albumin (CAR), and Procalcitonin-to-Albumin (PAR) Ratios Beyond ICU Admission in Critically Ill Patients.Journal of clinical medicine · 2026Article
- The C-reactive protein-triglyceride-glucose index (CTI) as a predictor of mortality and hospital stay in critically ill patients: a retrospective cohort study.Lipids in health and disease · 2025Article
- Low vitamin C concentrations and prognosis in critically ill children.Acute and critical care · 2025Article
- Role of the Lymphocyte Count-to-C-Reactive Protein Ratio in the Risk Stratification for High EASE Scores After Living Donor Liver Transplantation: A Retrospective Observational Cohort Study.Journal of clinical medicine · 2024Article
- Article
- Infection versus disease activity in systemic lupus erythematosus patients with fever.BMC rheumatology · 2024Article
- Comparison of Inflammatory Marker Scoring Systems and Conventional Inflammatory Markers in Patients over 65 Years of Age Admitted to the Intensive Care Unit: A Multicenter, Retrospective, Cohort Study.Journal of clinical medicine · 2024Article
- Predictive Value of PRISM-4, PIM-3, CRP, Albumin, CRP/Albumin Ratio and Lactate in Critically Ill Children.Children (Basel, Switzerland) · 2023Article
- Biological age is superior to chronological age in predicting hospital mortality of the critically ill.Internal and emergency medicine · 2023Article
- Current Status of Antibiotic Stewardship and the Role of Biomarkers in Antibiotic Stewardship Programs.Infection & chemotherapy · 2022Review
- Routine laboratory parameters predict intensive care unit admission and hospitalization in patients suffering stab injuries.Frontiers in immunology · 2022Article
- Plasma Neutrophil Gelatinase-Associated Lipocalin Is Useful for Predicting Mortality in Critically Ill Patients.Journal of clinical medicine · 2021Article
- Evaluation of serum presepsin, procalcitonin, copeptin, and high-sensitivity C-reactive protein for differentiating bacterial infection from disease activity in Egyptian patients with systemic lupus erythematosus.Clinical rheumatology · 2021Observational
- Article
- C-reactive protein concentration as a risk predictor of mortality in intensive care unit: a multicenter, prospective, observational study.BMC anesthesiology · 2020Observational
- Albumin supplementation may have limited effects on prolonged hypoalbuminemia in major burn patients: An outcome and prognostic factor analysis.Journal of the Chinese Medical Association : JCMA · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective was to assess the ability of potential clinical predictors and inflammatory markers within 24 h of intensive care unit (ICU) discharge to predict subsequent in-hospital mortality. DESIGN AND
settingA prospective cohort study of 603 consecutive patients who survived their first ICU admission, between 1 June and 31 December 2005, in a 22-bed multidisciplinary ICU of a university hospital. MEASUREMENTS AND
resultsA total of 26 in-hospital deaths after ICU discharge (4.3%) were identified. C-reactive protein (CRP) concentrations at ICU discharge were associated with subsequent in-hospital mortality in the univariate analysis (mean CRP concentrations of non-survivors=174 vs. survivors=85.6 mg/l, p=0.001). CRP concentrations remained significantly associated with post-ICU mortality (a 10-mg/l increment in CRP concentrations increased the odds ratio [OR] of death: 1.09, 95% confidence interval [CI]: 1.03-1.16); after adjusting for age, the Acute Physiology and Chronic Health Evaluation (APACHE) II predicted mortality, and the Delta Sequential Organ Failure Assessment (Delta SOFA) score. The area under the receiver operating characteristic curve of this multivariate model to discriminate between survivors and non-survivors after ICU discharge was 0.85 (95% CI: 0.73-0.96). The destination and timing of ICU discharge, and the Discharge SOFA score, white cell counts and fibrinogen concentrations at ICU discharge were not significantly associated with in-hospital mortality after ICU discharge.
conclusionsA high CRP concentration at ICU discharge was an independent predictor of in-hospital mortality after ICU discharge in our ICU.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.