ArticleInternational journal of gastrointestinal cancer2006
Estrogen and progesterone receptors expression in gastrointestinal stromal tumors and intramural gastrointestinal leiomyomas.
Article in International journal of gastrointestinal cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysis.BMC surgery · 2019Pooled it
- Myxoid epithelioid smooth muscle tumor with a novel MEF2A::NCOA2 fusion arising in the rectum: case report and literature review.Virchows Archiv : an international journal of pathology · 2026Review
- Age-dependent diminution of female prognostic advantage in gastrointestinal stromal tumors: a retrospective cohort analysis.Frontiers in immunology · 2025Article
- A Rare Case of Gastrointestinal Stromal Tumour in Pregnancy Presenting with Upper Gastrointestinal Bleeding.Journal of gastrointestinal cancer · 2012Article
- Retroperitoneal smooth muscle tumor of uncertain malignant potential after hysterectomy: a case report.Journal of medical case reports · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
Gastrointestinal stromal tumors (GISTs) and leiomyomas of the gastrointestinal tract both may present as intramural smooth muscle cell tumors. Immunohistochemically, these tumors demonstrate different spectrums of protein expression, which helps in differential diagnosis. Leiomyomas of the uterine type are similar by the spectrum of protein expression to gastrointestinal leiomyomas, but they express in addition both estrogen (ER) and progesterone (PR) receptors, which makes hormonal therapy possible for these tumors. In the current study, we investigated expression of ER and PR in GISTs and intramural gastrointestinal leiomyomas. Our data demonstrate that none of the 22 cases of gastrointestinal leiomyomas nor 19 cases of GIST were positive for either ER or PR expression. In contrast, leiomyomas of the uterine type were strongly positive for both ER and PR. Our data demonstrate that GIST and gastrointestinal leiomyomas differ from leiomyomas of the uterine type by the expression of ER and PR. Immunostaining for ER and PR may be a useful tool to distinguish these tumors and more precisely to plan further clinical interventions.
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