ArticleCaries research2007
Manganese affects Streptococcus mutans virulence gene expression.
Article in Caries research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Natural compounds: new therapeutic approach for inhibition ofFrontiers in pharmacology · 2025Review
- Effect of epigallocatechin gallate on dental biofilm of Streptococcus mutans: An in vitro study.BMC oral health · 2021Article
- Modulation of Biofilm Exopolysaccharides by the Streptococcus mutans vicX Gene.Frontiers in microbiology · 2015Article
- Xylella fastidiosa differentially accumulates mineral elements in biofilm and planktonic cells.PloS one · 2013Article
- Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo.Antimicrobial agents and chemotherapy · 2012Article
- Manganese transporters Yfe and MntH are Fur-regulated and important for the virulence of Yersinia pestis.Microbiology (Reading, England) · 2012Article
- Dental caries pathogenicity: a genomic and metagenomic perspective.International dental journal · 2011Review
- The delta subunit of RNA polymerase, RpoE, is a global modulator of Streptococcus mutans environmental adaptation.Journal of bacteriology · 2010Article
- Role of GlnR in acid-mediated repression of genes encoding proteins involved in glutamine and glutamate metabolism in Streptococcus mutans.Applied and environmental microbiology · 2010Article
- Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae.Journal of proteomics · 2010Article
- Genome-wide characterization of the SloR metalloregulome in Streptococcus mutans.Journal of bacteriology · 2010Article
- Role of the manganese efflux system mntE for signalling and pathogenesis in Streptococcus pneumoniae.Molecular microbiology · 2009Article
- A model of efficiency: stress tolerance by Streptococcus mutans.Microbiology (Reading, England) · 2008Review
- Effects of manganese on Streptococcus mutans planktonic and biofilm growth.Caries research · 2007Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
aimsStudies of trace metals in drinking water and tooth enamel have suggested a caries-promoting potential for manganese (Mn). Additionally, Mn has been shown to be essential for the expression of mutans streptococci virulence factors such as the glucan-binding lectin (GBL) of Streptococcus sobrinus. The Streptococcus mutans glucan-binding protein (Gbp) GbpC is the functional analogue of the S. sobrinus GBL. S. mutans Gbps have been shown to contribute to biofilm architecture and virulence. This study was undertaken to examine the effects of Mn on the transcription of genes encoding S. mutans Gbps, including gbpC, along with other critical S. mutans virulence genes.
methodsMicroarray analyses suggested the potential for an Mn effect on Gbp genes. Further investigation of the Mn effects on selected genes was undertaken by performing Northern blots, Western blots, and RT-PCR under conditions of planktonic and biofilm growth in Mn-depleted media or in media containing 50 mircoM Mn.
resultsMn resulted in increased expression of gbpC and gtfB, and decreased expression of wapA, in both planktonic and biofilm cultures. The expression levels of gbpA and gbpD were also decreased in the presence of Mn, but only in biofilms. The expression of gtfC was increased in the presence of Mn only in planktonic cultures. The spaP gene was expressed more highly in Mn-supplemented planktonic cultures but less in Mn-supplemented biofilms.
conclusionMn availability affects the expression of multiple S. mutans genes involved in adhesion and biofilm formation. Furthermore, these effects depend on the growth state of the organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.