ArticleProceedings of the National Academy of Sciences of the United States of America2007
Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 78 citations in OpenAlex.
- Microchimerism: The Hidden Cellular Dialogue Between Mother and Fetal That Shapes Lifelong Immunity.Expert reviews in molecular medicine · 2026Review
- The type 1 diabetes susceptibility locusFrontiers in immunology · 2024Article
- Adiponectin-expressing Treg cells in experimental thymic tumor model.Thoracic cancer · 2023Article
- H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity.Frontiers in immunology · 2023Article
- Modeling human T1D-associated autoimmune processes.Molecular metabolism · 2022Review
- Strength and Numbers: The Role of Affinity and Avidity in the 'Quality' of T Cell Tolerance.Cells · 2021Review
- Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance.Annals of the New York Academy of Sciences · 2020Review
- Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Central CD4Nature reviews. Immunology · 2019Review
- Thymically-derived Foxp3+ regulatory T cells are the primary regulators of type 1 diabetes in the non-obese diabetic mouse model.PloS one · 2019Article
- High Thymic Output of Effector CD4Journal of immunology research · 2019Article
- Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross.Cell reports · 2017Article
- Immunological implications of pregnancy-induced microchimerism.Nature reviews. Immunology · 2017Review
- Restoring Regulatory T Cells in Type 1 Diabetes.Current diabetes reports · 2016Review
- Nuclear transfer nTreg model reveals fate-determining TCR-β and novel peripheral nTreg precursors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Mechanisms of autoimmunity in the non-obese diabetic mouse: effector/regulatory cell equilibrium during peak inflammation.Immunology · 2016Review
- Unstable FoxP3+ T regulatory cells in NZW mice.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Re-examining the Nature and Function of Self-Reactive T cells.Trends in immunology · 2016Review
- Article
- Interindividual variation in human T regulatory cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
FoxP3(+)CD4(+) regulatory T cells (Tregs) play a key role in the maintenance of peripheral self-tolerance, and it has been suggested that diabetes-susceptible nonobese diabetic (NOD) mice are defective in the generation and numbers of Tregs. We found thymic selection of Tregs to be under genetic control. Fetal thymic organ cultures on the NOD background required 3- to 10-fold more antigen than corresponding cultures on the B6 background for optimal induction of Tregs, but once the threshold for induction was reached the NOD background yielded close to 10-fold more Tregs. This increased selection of Tregs was also found in nontransgenic NOD mice in fetal through adult stages. This trait did not map to the MHC, idd3, or the chromosome 3 (Chr3) regions that control clonal deletion, but mainly to two regions on Chr1 and Chr11. Thus, NOD mice do not have a global defect in the generation or maintenance of Tregs; if anything, they show the opposite.
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