ArticleThe Journal of physiology2008
Transition to seizures in the isolated immature mouse hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 85 citations in OpenAlex.
- Review
- Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal CortexThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Focal seizures are organized by feedback between neural activity and ion concentration changes.eLife · 2022Article
- A novel methodology to describe neuronal networks activity reveals spatiotemporal recruitment dynamics of synchronous bursting states.Journal of computational neuroscience · 2021Article
- Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular MgBMC neuroscience · 2021Article
- Dysregulation of GABAergic Signaling in Neurodevelomental Disorders: Targeting Cation-Chloride Co-transporters to Re-establish a Proper E/I Balance.Frontiers in cellular neuroscience · 2021Review
- Microglial contributions to aberrant neurogenesis and pathophysiology of epilepsy.Neuroimmunology and neuroinflammation · 2020Article
- Neuromodulation with electromagnetic stimulation for seizure suppression: From electrode to magnetic coil.IBRO reports · 2019Review
- Evolving Mechanistic Concepts of Epileptiform Synchronization and their Relevance in Curing Focal Epileptic Disorders.Current neuropharmacology · 2019Review
- GABANeuroscience bulletin · 2018Article
- Classifying dynamic transitions in high dimensional neural mass models: A random forest approach.PLoS computational biology · 2018Article
- Chemogenetic Recruitment of Specific Interneurons Suppresses Seizure Activity.Frontiers in cellular neuroscience · 2018Article
- Understanding the Generation of Network Bursts by Adaptive Oscillatory Neurons.Frontiers in neuroscience · 2018Article
- Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis.Journal of biomedical science · 2017Review
- Pumilio2-deficient mice show a predisposition for epilepsy.Disease models & mechanisms · 2017Article
- Interneuronal Network Activity at the Onset of Seizure-Like Events in Entorhinal Cortex Slices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Spatiotemporal changes in regularity of gamma oscillations contribute to focal ictogenesis.Scientific reports · 2017Article
- Specific imbalance of excitatory/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy.Journal of neurophysiology · 2016Review
- Transgenic labeling of parvalbumin-expressing neurons with tdTomato.Neuroscience · 2016Article
- GABAergic networks jump-start focal seizures.Epilepsia · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural dynamics and mechanisms responsible for the transition from the interictal to the ictal state (seizures) are unresolved questions in epilepsy. It has been suggested that a shift from inhibitory to excitatory GABAergic drive can promote seizure generation. In this study, we utilized an experimental model of temporal lobe epilepsy which produces recurrent seizure-like events in the isolated immature mouse hippocampus (P8-16), perfused with low magnesium ACSF, to investigate the cellular dynamics of seizure transition. Whole-cell and perforated patch recordings from CA1 pyramidal cells and from fast- and non-fast-spiking interneurons in the CA1 stratum oriens hippocampal region showed a change in intracellular signal integration during the transition period, starting with dominant phasic inhibitory synaptic input, followed by dominant phasic excitation prior to a seizure. Efflux of bicarbonate ions through the GABA A receptor did not fully account for this excitation and GABAergic excitation via reversed IPSPs was also excluded as the prime mechanism generating the dominant excitation, since somatic and dendritic GABA A responses to externally applied muscimol remained hyperpolarizing throughout the transition period. In addition, abolishing EPSPs in a single neuron by intracellularly injected QX222, revealed that inhibitory synaptic drive was maintained throughout the entire transition period. We suggest that rather than a major shift from inhibitory to excitatory GABAergic drive prior to seizure onset, there is a change in the interaction between afferent synaptic inhibition, and afferent and intrinsic excitatory processes in pyramidal neurons and interneurons, with maintained inhibition and increasing, entrained 'overpowering' excitation during the transition to seizure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.