ArticleArchives of disease in childhood2007
Severe complications of chickenpox in hospitalised children in the UK and Ireland.
Article in Archives of disease in childhood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Estimation of the burden of varicella in Europe before the introduction of universal childhood immunization.BMC infectious diseases · 2017Pooled it
- Varicella Skin Complications in Childhood: A Case Series and a Systematic Review of the Literature.International journal of molecular sciences · 2016Pooled it
- Acute cerebellitis in varicella: a ten year case series and systematic review of the literature.Italian journal of pediatrics · 2014Pooled it
- Safety, immunogenicity and immediate pain of intramuscular versus subcutaneous administration of a measles-mumps-rubella-varicella vaccine to children aged 11-21 months.European journal of pediatrics · 2010Trial
- Preventive Healthcare and Disability: Challenges and Opportunities.Healthcare (Basel, Switzerland) · 2025Article
- Immunity to Varicella Zoster Virus in Healthcare Workers: A Systematic Review and Meta-Analysis (2024).Vaccines · 2024Review
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- The Clinical and Economic Burden of Antibiotic Use in Pediatric Patients With Varicella Infection: A Retrospective Cohort Analysis of Real-World Data in England.The Journal of infectious diseases · 2024Article
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- Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis.Infectious diseases and therapy · 2024Article
- Article
- Case Report: A Case Report: Chickenpox Acquired Through Surface Contamination: A Rare Clincal Observation.F1000Research · 2022Article
- Risk Factors for Poor Prognosis of Severe Infection in Children With Idiopathic Nephrotic Syndrome: A Double-Center, Retrospective Study.Frontiers in pediatrics · 2021Article
- Vaccination in people with disability: a review.Human vaccines & immunotherapeutics · 2020Review
- Burden of varicella complications in secondary care, England, 2004 to 2017.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Varicella zoster virus vaccines: an update.ImmunoTargets and therapy · 2019Article
- Appetitive information seeking behaviour reveals robust daily rhythmicity for Internet-based food-related keyword searches.Royal Society open science · 2018Article
- Article
- Acute cerebellitis in children: an eleven year retrospective multicentric study in Italy.Italian journal of pediatrics · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo estimate the annual incidence of hospitalisations due to severe complications of varicella, describe the complications and estimate annual mortality.
methodsActive surveillance throughout the UK and Ireland for 13 months by paediatricians notifying cases to the British Paediatric Surveillance Unit and completing a questionnaire. The case definition was any child aged <16 years hospitalised with complicated varicella, as defined by a list of conditions, or admitted to ICU/HDU with varicella.
results188 cases were notified for the surveillance period, of which 112 (0.82/100 000 children/year) met the case definition and were not duplicates. Confirmed cases had a median age of 3 years (range 0-14). The complications were: bacteraemia/septic shock (n = 30), pneumonia (n = 30), encephalitis (n = 26), ataxia (n = 25), toxic shock syndrome/toxin-mediated disease (n = 14), necrotising fasciitis (n = 7), purpura fulminans/disseminated coagulopathy (n = 5), fulminant varicella (n = 5) and neonatal varicella (n = 3). 52 children (46%) had additional bacterial infections. Six deaths were due, or possibly due, to varicella, including one intrauterine death. Four of the other five children who died (ages 2-14 years) had a pre-existing medical condition. Sequelae on discharge were reported for 41 cases (40%), most frequently ataxia or skin scarring. The median length of hospital stay was 7 days (range 1-68).
conclusionsThis study provides a minimum estimate of severe complications and death resulting from varicella in children in the UK and Ireland. Most complications, excluding deaths, occur in otherwise healthy children and thus would be preventable only through a universal childhood immunisation programme.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.