ArticleNeuropharmacology2008
Substrate-mediated regulation of gamma-aminobutyric acid transporter 1 in rat brain.
Article in Neuropharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Repeated oral administration of gamma-aminobutyric acid (GABA) does not cause reproductive or developmental toxicity in rats.Toxicology reports · 2026Article
- Intracortical and intercortical networks in patients after stroke: a concurrent TMS-EEG study.Journal of neuroengineering and rehabilitation · 2023Article
- Transcriptomic Analysis of the Effect of GAT-2 Deficiency on Differentiation of Mice Naïve T Cells Into Th1 CellsFrontiers in immunology · 2021Article
- Regulation of Glutamate, GABA and Dopamine Transporter Uptake, Surface Mobility and Expression.Frontiers in cellular neuroscience · 2021Review
- Chronic diazepam administration increases the expression of Lcn2 in the CNS.Pharmacology research & perspectives · 2017Article
- γ-aminobutyric acid transporter-1 is involved in anxiety-like behaviors and cognitive function in knockout mice.Experimental and therapeutic medicine · 2015Article
- Serotonin, neural markers, and memory.Frontiers in pharmacology · 2015Review
- Perinatal hypoxia: different effects of the inhibitors of GABA transporters GAT1 and GAT3 on the initial velocity of [3H]GABA uptake by cortical, hippocampal, and thalamic nerve terminals.Croatian medical journal · 2014Article
- Effects of progesterone on glutamate transporter 2 and gamma-aminobutyric acid transporter 1 expression in the developing rat brain after recurrent seizures.Neural regeneration research · 2012Article
- Localization and function of GABA transporters in the globus pallidus of parkinsonian monkeys.Experimental neurology · 2010Article
- Enhanced tonic GABAA inhibition in typical absence epilepsy.Nature medicine · 2009Article
- GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET.The Journal of general physiology · 2009Article
- Plasmalemmal and vesicular gamma-aminobutyric acid transporter expression in the developing mouse retina.The Journal of comparative neurology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The uptake of neurotransmitter by plasma membrane transporters is a principal method for regulating extracellular transmitter levels. Neurotransmitter-mediated signals in turn are able to regulate transporter expression and function. Thus, there is a continual interplay between transporters and the transmitters they transport. Previously we showed that extracellular gamma-aminobutyric acid (GABA) increases the expression of the GABA transporter 1 (GAT1) on a time scale of minutes by acting via the transporter to slow transporter internalization. This mechanism requires in part direct tyrosine phosphorylation of the transporter. In the present study we show that the presence of GABA on a longer time scale causes a net decrease in GAT surface expression. The decrease in expression represents the contributions of transporter-mediated up-regulation and a more substantial GABA-receptor-mediated down-regulation. This receptor-mediated down-regulation is the result of both changes in the rates of transporter trafficking and in the number of transporters available for trafficking. As with transporter-mediated regulation of GAT1, the receptor-mediated regulation is associated with changes in the direct phosphorylation of GAT1. These data suggest that multiple pathways, perhaps converging upon mechanisms involving protein phosphorylation, act to regulate GAT1 expression in neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.