ArticleDevelopmental biology2007
Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Unlocking the genetic secrets of Dorper sheep: insights into wool shedding and hair follicle development.Frontiers in veterinary science · 2024Article
- Examining the Effect ofMolecules (Basel, Switzerland) · 2023Article
- Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia.EMBO molecular medicine · 2021Article
- Recent Advances in Stem Cell Therapy for Limbal Stem Cell Deficiency: A Narrative Review.Ophthalmology and therapy · 2020Review
- Genetically modified laboratory mice with sebaceous glands abnormalities.Cellular and molecular life sciences : CMLS · 2016Review
- Cofactors of LIM Domains Associate with Estrogen Receptor α to Regulate the Expression of Noncoding RNA H19 and Corneal Epithelial Progenitor Cell Function.The Journal of biological chemistry · 2016Article
- LIM Homeobox Domain 2 Is Required for Corneal Epithelial Homeostasis.Stem cells (Dayton, Ohio) · 2016Article
- Article
- The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.PLoS genetics · 2014Article
- Wounding the cornea to learn how it heals.Experimental eye research · 2014Review
- Architectural niche organization by LHX2 is linked to hair follicle stem cell function.Cell stem cell · 2013Article
- Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury.Development (Cambridge, England) · 2011Article
- Alk is a transcriptional target of LMO4 and ERα that promotes cocaine sensitization and reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Cyclic expression of lhx2 regulates hair formation.PLoS genetics · 2010Article
- Gene expression profiles of dental follicle cells before and after osteogenic differentiation in vitro.Clinical oral investigations · 2009Article
- Role of ldb1 in adult intestinal homeostasis.International journal of biological sciences · 2009Article
- Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
The homeostasis of both cornea and hair follicles depends on a constant supply of progeny cells produced by populations of keratin (K) 14-expressing stem cells localized in specific niches. To investigate the potential role of Co-factors of LIM domains (Clims) in epithelial tissues, we generated transgenic mice expressing a dominant-negative Clim molecule (DN-Clim) under the control of the K14 promoter. As expected, the K14 promoter directed high level expression of the transgene to the basal cells of cornea and epidermis, as well as the outer root sheath of hair follicles. In corneal epithelium, the transgene expression causes decreased expression of adhesion molecule BP180 and defective hemidesmosomes, leading to detachment of corneal epithelium from the underlying stroma, which in turn causes blisters, wounds and an inflammatory response. After a period of epithelial thinning, the corneal epithelium undergoes differentiation to an epidermis-like structure. The K14-DN-Clim mice also develop progressive hair loss due to dysfunctional hair follicles that fail to generate hair shafts. The number of hair follicle stem cells is decreased by at least 60% in K14-DN-Clim mice, indicating that Clims are required for hair follicle stem cell maintenance. In addition, Clim2 interacts with Lhx2 in vivo, suggesting that Clim2 is an essential co-factor for the LIM homeodomain factor Lhx2, which was previously shown to play a role in hair follicle stem cell maintenance. Together, these data indicate that Clim proteins play important roles in the homeostasis of corneal epithelium and hair follicles.
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