ArticleFEBS letters2007
Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen.
Article in FEBS letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- UBC9-mediated p53 SUMOylation drives tubular senescence and exacerbates acute kidney injury in mice.Acta pharmacologica Sinica · 2026Article
- Article
- SUMOylation-Mediated Response to Mitochondrial Stress.International journal of molecular sciences · 2020Review
- Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway.Nature communications · 2018Article
- Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Oxidative stress response and Nrf2 signaling in aging.Free radical biology & medicine · 2015Review
- Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- PML, SUMOylation, and Senescence.Frontiers in oncology · 2013Article
- Effects of age and caloric restriction on mitochondrial protein oxidative damage in mice.Mechanisms of ageing and development · 2012Article
- Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress.Free radical biology & medicine · 2011Article
- Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.The Journal of biological chemistry · 2010Article
- The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective.Cardiovascular research · 2010Review
- Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart.Mechanisms of ageing and development · 2008Article
- Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver.Mechanisms of ageing and developmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In the present study, we demonstrate for the first time that aging increases the levels of ubiquitinated protein in the spleen, and that dietary restriction (DR) significantly reduces these age-related increases in ubiquitinated protein. Sumoylated protein, proteasome subunits, and a protein essential for proteasome biogenesis (POMP1) were also increased with age in the spleen but were not significantly affected by DR. Chymotrypsin-like proteasome activity was elevated in the aged spleen, and was not significantly altered by DR. Together, these data demonstrate for the first time the multiple effects of aging and DR on ubiquitination, sumoylation, and the proteasome in the spleen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.