ReviewNeuromolecular medicine2008
The sympathetic nervous system and pain.
Review in Neuromolecular medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05730829 (Pain Informed Movement for People With Knee Osteoarthritis), which is not on this map. Cited by 94 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pain Informed Movement for People With Knee Osteoarthritis: A Pilot and Feasibility Randomized Controlled Trial
Who cites it
94 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Prevalence of Irritable Bowel Syndrome Among Chinese University Students: A Systematic Review and Meta-Analysis.Frontiers in public health · 2022Pooled it
- The sympathetic nervous system and tendinopathy: a systematic review.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationPooled it
- Immediate Effects of Dry Needling on the Autonomic Nervous System and Mechanical Hyperalgesia: A Randomized Controlled Trial.International journal of environmental research and public health · 2021Trial
- Does moxonidine reduce Achilles tendon or musculoskeletal pain in women with polycystic ovarian syndrome? A secondary analysis of a randomised controlled trial.BMC endocrine disorders · 2020Trial
- The effect of a single spinal manipulation on cardiovascular autonomic activity and the relationship to pressure pain threshold: a randomized, cross-over, sham-controlled trial.Chiropractic & manual therapies · 2020Trial
- Effects of sedation on subjective perception of pain intensity and autonomic nervous responses to pain: A preliminary study.PloS one · 2017Trial
- Pain Intensity Recognition Rates via Biopotential Feature Patterns with Support Vector Machines.PloS one · 2015Trial
- Prevalence of dysautonomia in chronic musculoskeletal pain: a cross-sectional study.Rheumatology (Oxford, England) · 2026Article
- Sedation Strategy, Procedural Comfort, and Clinically Detected Radial Artery Spasm During Transradial Coronary Angiography: A Prospective Observational Study.Journal of clinical medicine · 2026Article
- Cancer-induced nerve injury unveils a sympathetic-to-sensory nerve axis in a mouse model of head and neck squamous cell carcinoma.Science translational medicine · 2026Article
- Multimodal Detection of Pain and Anticipation Anxiety from Ultra-Short Duration Wearable Sensors Measurements.Sensors (Basel, Switzerland) · 2026Article
- Pain assessment using physiological responses/markers in different types of pain: a scoping review.NPJ digital medicine · 2026Article
- Understanding Sleep Challenges in Pediatric Palliative Care: A Patient-Focused Scoping Review and Implications for Practice.Journal of clinical medicine · 2026Review
- The involvement of attentional biases in endogenous pain inhibition and autonomic reactivity.PloS one · 2026Article
- An Effective Microcurrent Stimulation Method for Inducing Non-Pharmacological Parasympathetic Nervous System Activity for Pain Relief.Bioengineering (Basel, Switzerland) · 2025Article
- Variations and Challenges in the Management of Traumatic Bladder Injuries: An Experience From a Large Trauma Center.Cureus · 2025Article
- Chronic Coccygodynia and ganglion impar block: How does contrast material distribution affect treatment outcomes?Pain practice : the official journal of World Institute of Pain · 2025Article
- Pathophysiology and management of burn injury-induced pain.Burns open : an international open access journal for burn injuries · 2025Article
- A Multimodal Deep Learning Approach to Intraoperative Nociception Monitoring: Integrating Electroencephalogram, Photoplethysmography, and Electrocardiogram.Sensors (Basel, Switzerland) · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sympathetic nervous system (SNS) and pain interact on many levels of the neuraxis. In healthy subjects, activation of the SNS in the brain usually suppresses pain mainly by descending inhibition of nociceptive transmission in the spinal cord. Furthermore, some experimental data even suggest that the SNS might control peripheral inflammation and nociceptive activation. However, even subtle changes in pathophysiology can dramatically change the effect of SNS on pain, and vice versa. In the periphery, inflammation or nociceptive activation is enhanced, spinal descending inhibition is reversed to spinal facilitation, and finally the awareness of all these changes will induce anxiety, which furthermore amplifies pain perception, affects pain behavior, and depresses mood. Unraveling the detailed molecular mechanisms of how this interaction of SNS and pain is established in health and disease will help us to treat pain more successfully in the future.
Indexed as
Identifiers
17990126What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.