ReviewPediatric nephrology (Berlin, Germany)2008
Hypertension in children with chronic kidney disease: pathophysiology and management.
Review in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 94 citations in OpenAlex.
- Erythropoietin in children with hemolytic uremic syndrome: a pilot randomized controlled trial.Pediatric nephrology (Berlin, Germany) · 2022Trial
- Randomized, double-blind, controlled study of losartan in children with proteinuria.Clinical journal of the American Society of Nephrology : CJASN · 2010Trial
- Characterizing children with chronic kidney disease and severe proteinuria in the United States: a retrospective analysis using electronic health records.Pediatric nephrology (Berlin, Germany) · 2026Article
- Nonsurgical Management of Drug-induced Gingival Enlargement in a Young Adolescent with Chronic Kidney Disease: A Case Report.International journal of clinical pediatric dentistry · 2025Article
- Nutritional management of the child with chronic kidney disease and on dialysis.Pediatric nephrology (Berlin, Germany) · 2025Review
- Antihypertensive Effects of a Sodium Thiosulfate-Loaded Nanoparticle in a Juvenile Chronic Kidney Disease Rat Model.Antioxidants (Basel, Switzerland) · 2024Article
- Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure.Clinical science (London, England : 1979) · 2024Article
- Anti-Hypertensive Property of an NO Nanoparticle in an Adenine-Induced Chronic Kidney Disease Young Rat Model.Antioxidants (Basel, Switzerland) · 2023Article
- Perioperative anesthesia care for the pediatric patient undergoing a kidney transplantation: An educational review.Paediatric anaesthesia · 2021Review
- Genetic susceptibility of hypertension-induced kidney disease.Physiological reports · 2021Review
- Hypertensive Crisis in Pediatric Patients: An Overview.Frontiers in pediatrics · 2020Review
- Oxidative stress in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Management of Hypertension in CAKUT: Protective Factor for CKD.Frontiers in pediatrics · 2019Review
- Blood pressure management in children on dialysis.Pediatric nephrology (Berlin, Germany) · 2018Review
- What has changed in the prevalence of hypertension in dialyzed children during the last decade?Renal failure · 2017Article
- Development of tandem mass spectrometry-based creatinine measurement using dried blood spot for newborn mass screening.Pediatric research · 2017Article
- Hypertension in pediatric patients with chronic kidney disease: management challenges.International journal of nephrology and renovascular disease · 2017Review
- Finding covert fluid: methods for detecting volume overload in children on dialysis.Pediatric nephrology (Berlin, Germany) · 2016Observational
- Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Renal and Cardiovascular Morbidities Associated withFrontiers in pediatrics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arterial hypertension is very common in children with all stages of chronic kidney disease (CKD). While fluid overload and activation of the renin-angiotensin system have long been recognized as crucial pathophysiological pathways, sympathetic hyperactivation, endothelial dysfunction and chronic hyperparathyroidism have more recently been identified as important factors contributing to CKD-associated hypertension. Moreover, several drugs commonly administered in CKD, such as erythropoietin, glucocorticoids and cyclosporine A, independently raise blood pressure in a dose-dependent fashion. Because of the deleterious consequences of hypertension on the progression of renal disease and cardiovascular outcomes, an active screening approach should be adapted in patients with all stages of CKD. Before one starts antihypertensive treatment, non-pharmacological options should be explored. In hemodialysis patients a low salt diet, low dialysate sodium and stricter dialysis towards dry weight can often achieve adequate blood pressure control. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers are first-line therapy for patients with proteinuria, due to their additional anti-proteinuric properties. Diuretics are a useful alternative for non-proteinuric patients or as an add-on to renin-angiotensin system blockade. Multiple drug therapy is often needed to maintain blood pressure below the 90th percentile target, but adequate blood pressure control is essential for better renal and cardiovascular long-term outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.