ArticlePediatric nephrology (Berlin, Germany)2008
Frequent hemodialysis with NxStage system in pediatric patients receiving maintenance hemodialysis.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 63 citations in OpenAlex.
- Short, frequent, 5-days-per-week, in-center hemodialysis versus 3-days-per week treatment: a randomized crossover pilot trial through the Midwest Pediatric Nephrology Consortium.Pediatric nephrology (Berlin, Germany) · 2017Trial
- Dialysis-associated cardiovascular disease risk in children: mechanism and management.Pediatric nephrology (Berlin, Germany) · 2026Review
- Comparing outcomes with different dialysis modalities in children with kidney failure: home hemodialysis versus in-center hemodiafiltration or conventional hemodialysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- How dialysis frequency and duration impact uremic toxin and fluid removal: a pediatric perspective.Pediatric nephrology (Berlin, Germany) · 2025Review
- Monitoring dialysis adequacy: history and current practice.Pediatric nephrology (Berlin, Germany) · 2021Article
- Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup.Pediatric nephrology (Berlin, Germany) · 2019Article
- Assessment and management of fluid overload in children on dialysis.Pediatric nephrology (Berlin, Germany) · 2019Review
- Dalteparin anticoagulation in paediatric home haemodialysis.Pediatric nephrology (Berlin, Germany) · 2018Observational
- Hypertension in Pediatric Dialysis Patients: Etiology, Evaluation, and Management.Current hypertension reports · 2018Review
- Blood pressure management in children on dialysis.Pediatric nephrology (Berlin, Germany) · 2018Review
- Health-related quality of life in patients with pediatric onset of end-stage renal disease: state of the art and recommendations for clinical practice.Pediatric nephrology (Berlin, Germany) · 2016Review
- Interdialytic weight gain in oligoanuric children and adolescents on chronic hemodialysis.Pediatric nephrology (Berlin, Germany) · 2015Article
- Oxalate quantification in hemodialysate to assess dialysis adequacy for primary hyperoxaluria.American journal of nephrology · 2014Article
- Home haemodialysis.Pediatric nephrology (Berlin, Germany) · 2013Review
- Intradialytic hypotension.Pediatric nephrology (Berlin, Germany) · 2011Review
- Uncontrolled hypertension in children on hemodialysis.Nature reviews. Nephrology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence from adult hemodialysis (HD) patient studies reveal improved biochemical control and reported health-related quality of life after transition from conventional thrice weekly to daily home maintenance HD treatment. Published pediatric frequent dialysis experiences demonstrate similar improvement but all used conventional HD machines, which employ a treated municipal water supply, thereby frequently exposing patients to proinflammatory components. We report our pediatric experience with six-times-weekly HD using the NxStage system, which uses sterile dialysis fluid to provide dialysis in the home or center setting. Four patients (weight range 38-61.4 kg) completed the 16-week study. Patients exhibited progressive reductions in casual pretreatment systolic and diastolic blood pressures, discontinuation of antihypertensive medications, and decreased blood pressure load by ambulatory blood pressure monitoring. Mean serum phosphorus improved without change in phosphorus binder medication, and all three patients with a normalized protein catabolic rate <1 g/kg per day at the beginning of the study improved to a normalized protein catabolic rate (nPCR) of >1.1 g/kg per day. Patients reported no adverse effects. Variable changes in proinflammatory cytokine levels were observed. We suggest that frequent HD with the NxStage system be considered for children who would benefit from home-based maintenance dialysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.