SynthesisSeminars in immunopathology2008
Defining a role for ambient TLR ligand exposures in the genesis and prevention of allergic diseases.
Synthesis in Seminars in immunopathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Associations between maternal and environmental exposures on atopic disease in the offspring of mothers with asthma.Immunity, inflammation and disease · 2021Article
- Article
- Are cats and dogs the major source of endotoxin in homes?Indoor air · 2013Article
- House dust bioactivities predict skin prick test reactivity for children with high risk of allergy.The Journal of allergy and clinical immunology · 2012Article
- Invariant NKT cells are required for airway inflammation induced by environmental antigens.The Journal of experimental medicine · 2011Article
- Regulatory T cells contribute to allergen tolerance induced by daily airway immunostimulant exposures.American journal of respiratory cell and molecular biology · 2011Article
- Does exposure to cats or dogs in early life alter a child's risk of atopic dermatitis?The Journal of pediatrics · 2011Article
- Regulation of aeroallergen immunity by the innate immune system: laboratory evidence for a new paradigm.Journal of innate immunity · 2010Review
- Allergen tolerance versus the allergic march: the hygiene hypothesis revisited.Current allergy and asthma reports · 2008Review
- Airway house dust extract exposures modify allergen-induced airway hypersensitivity responses by TLR4-dependent and independent pathways.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen.Journal of Zhejiang University. Science. B · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Environmental variables responsible for the increasing allergic disease burden observed in developed countries over the last century have yet to be adequately characterized. Meta-analyses of epidemiological studies presented in the first half of this paper demonstrate a correlation between farm-associated exposures (i.e., livestock, pets, unpasteurized milk, and endotoxin) and a reduction in allergic risk during childhood. Laboratory investigations discussed in the second half of the paper characterize the intrinsic immunostimulatory activities of living environments. Considered together, experimental findings presented herein suggest a novel paradigm by which early life home exposures to microbial products and other allergen-nonspecific immunostimulants modify allergic risk.
Indexed as
Identifiers
17989979What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.