ArticlePloS one2007
Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 86 citations in OpenAlex.
- Probabilistic alignment leads to improved accuracy and read coverage for bisulfite sequencing data.BMC bioinformatics · 2013Trial
- Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization.The Journal of cell biology · 2024Article
- Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish.Communications biology · 2024Article
- A systematic scientometric review of paternal inheritance of acquired metabolic traits.BMC biology · 2023Review
- Review
- Epigenetics in Alzheimer's Disease.Frontiers in aging neuroscience · 2022Review
- Rearing environment affects the genetic architecture and plasticity of DNA methylation in Chinook salmon.Heredity · 2021Article
- Genome evolution of blind subterranean mole rats: Adaptive peripatric versus sympatric speciation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Male germline transmits fetal alcohol epigenetic marks for multiple generations: a review.Addiction biology · 2016Review
- Epigenetics and Epilepsy.Cold Spring Harbor perspectives in medicine · 2015Review
- Whole genome sequencing and methylome analysis of the wild guinea pig.BMC genomics · 2014Article
- H2A.B facilitates transcription elongation at methylated CpG loci.Genome research · 2014Article
- Epigenetic modification, dehydration, and molecular crowding effects on the thermodynamics of i-motif structure formation from C-rich DNA.Biochemistry · 2014Article
- The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern.DNA research : an international journal for rapid publication of reports on genes and genomes · 2013Article
- Genetic and epigenetic control of metabolic health.Molecular metabolism · 2013Review
- Comparative methylomics between domesticated and wild silkworms implies possible epigenetic influences on silkworm domestication.BMC genomics · 2013Article
- Human native lipoprotein-induced de novo DNA methylation is associated with repression of inflammatory genes in THP-1 macrophages.BMC genomics · 2011Article
- Epigenetic mechanisms involved in developmental nutritional programming.World journal of diabetes · 2011Article
- Simultaneous single-molecule mapping of protein-DNA interactions and DNA methylation by MAPit.Current protocols in molecular biology · 2011Article
- Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay.Analytical chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Site-specific methylation of cytosines is a key epigenetic mark of vertebrate DNA. While a majority of the methylated residues are in the symmetrical (meC)pG:Gp(meC) configuration, a smaller, but significant fraction is found in the CpA, CpT and CpC asymmetric (non-CpG) dinucleotides. CpG methylation is reproducibly maintained by the activity of the DNA methyltransferase 1 (Dnmt1) on the newly replicated hemimethylated substrates (meC)pG:GpC. On the other hand, establishment and hereditary maintenance of non-CpG methylation patterns have not been analyzed in detail. We previously reported the occurrence of site- and allele-specific methylation at both CpG and non-CpG sites. Here we characterize a hereditary complex of non-CpG methylation, with the transgenerational maintenance of three distinct profiles in a constant ratio, associated with extensive CpG methylation. These observations raised the question of the signal leading to the maintenance of the pattern of asymmetric methylation. The complete non-CpG pattern was reinstated at each generation in spite of the fact that the majority of the sperm genomes contained either none or only one methylated non-CpG site. This observation led us to the hypothesis that the stable CpG patterns might act as blueprints for the maintenance of non-CpG DNA methylation. As predicted, non-CpG DNA methylation profiles were abrogated in a mutant lacking Dnmt1, the enzymes responsible for CpG methylation, but not in mutants defective for either Dnmt3a or Dnmt2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.