Trial reportJournal of perinatology : official journal of the California Perinatal Association2008
A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Higher versus lower sodium intake for preterm infants.The Cochrane database of systematic reviews · 2023Pooled it
- Early volume expansion for prevention of morbidity and mortality in very preterm infants.The Cochrane database of systematic reviews · 2004Pooled it
- Albumin versus normal saline for dehydrated term infants with metabolic acidosis due to acute diarrhea.Journal of perinatology : official journal of the California Perinatal Association · 2009Trial
- Anesthesia Practices for Preterm Infants: A Survey in the Nordic Countries and Review of the Literature.Acta anaesthesiologica Scandinavica · 2026Review
- Role of Volume Replacement during Neonatal Resuscitation in the Delivery Room.Children (Basel, Switzerland) · 2022Review
- Successful Resuscitation in a Model of Asphyxia and Hemorrhage to Test Different Volume Resuscitation Strategies. A Study in Newborn Piglets After Transition.Frontiers in pediatrics · 2018Article
- Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2016Article
- Hypoproteinemia on the first day of life and adverse outcome in very preterm infants admitted to the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2012Article
- Albumin versus saline: an open question.Journal of perinatology : official journal of the California Perinatal Association · 2008Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe compared responses to bolus infusion of 5% albumin (ALB) or normal saline (NS) for hypotension in neonates. STUDY
designHypotensive infants were given 10 ml kg(-1) of NS or ALB. A second bolus was given for persistent hypotension. Dopamine therapy was started for hypotension after the second bolus. The primary response was increase in arterial blood pressure toward normal range 1 h postinfusion. Secondary measures included duration of normotension, meeting criteria for second bolus, meeting criteria for vasopressor support and cost comparison.
resultThose receiving ALB (N=49 ALB and 52 NS) were more likely to achieve a normotensive state (ALB=57.1%, NS=32.1% P=0.01) 1 h following the initial bolus therapy. Subsequently, the NS group was also more likely to qualify for vasopressor infusion (ALB=24.5%, NS=44.2% P=0.02). Overall cost for either therapy was equivalent.
conclusionIn hypotensive neonates, ALB results in a greater likelihood of achieving normotension and decreased subsequent use of vasopressors when compared to NS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.