ArticleAJNR. American journal of neuroradiology2008
In vivo demonstration of neuroinflammatory molecule expression in brain abscess with diffusion tensor imaging.
Article in AJNR. American journal of neuroradiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 38 citations in OpenAlex.
- Differential gene expression in glioblastoma defined by ADC histogram analysis: relationship to extracellular matrix molecules and survival.AJNR. American journal of neuroradiology · 2012Trial
- Correlation of quantitative diffusion tensor tractography with clinical grades of subacute sclerosing panencephalitis.AJNR. American journal of neuroradiology · 2011Trial
- Dynamic Imaging of Blood Coagulation Within the Hematoma of Patients With Acute Hemorrhagic Stroke.Stroke · 2024Article
- Diffusion Tensor and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Correlate with Molecular Markers of Inflammation in the Synovium.Diagnostics (Basel, Switzerland) · 2022Article
- To Contrast or Not to Contrast? On the Role of Contrast Enhancement in Hand MRI Studies of Patients with Rheumatoid Arthritis.Diagnostics (Basel, Switzerland) · 2022Article
- Differentiation of Neoplastic and Non-neoplastic Intracranial Enhancement Lesions Using Three-Dimensional Pseudo-Continuous Arterial Spin Labeling.Frontiers in neuroscience · 2022Article
- COVID-19-Associated Acute Brain Dysfunction Related to Sepsis.Journal of clinical medicine research · 2021Review
- Imaging in sepsis-associated encephalopathy--insights and opportunities.Nature reviews. Neurology · 2013Review
- Demonstration of different histological layers of the pachygyria/agyria cortex using diffusion tensor MR imaging.Surgical and radiologic anatomy : SRA · 2013Article
- Differentiation of tumefactive demyelinating lesions from high-grade gliomas with the use of diffusion tensor imaging.AJNR. American journal of neuroradiology · 2012Article
- Apparent diffusion coefficient with higher b-value correlates better with viable cell count quantified from the cavity of brain abscess.AJNR. American journal of neuroradiology · 2011Article
- Differentiation of brain abscesses from necrotic glioblastomas and cystic metastatic brain tumors with diffusion tensor imaging.AJNR. American journal of neuroradiology · 2011Article
- [Value of MR spectroscopy in infectious and inflammatory brain diseases].Der Radiologe · 2010Article
- In vivo proton MR spectroscopy evaluation of pyogenic brain abscesses: a report of 194 cases.AJNR. American journal of neuroradiology · 2010Article
- A new era in neuroradiology: ex vivo validation of in vivo imaging research.AJNR. American journal of neuroradiology · 2008Article
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11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeNeuroinflammatory molecules, including tumor necrosis factor-alpha, interleukin1-beta, lymphocyte function associated molecule-1, and intercellular cell adhesion molecule-1 contribute to the development of brain abscess. We hypothesized that the high fractional anisotropy (FA) in the brain abscess cavity reflects the upregulation of these neuroinflammatory molecules. MATERIALS AND
methodsDiffusion tensor imaging (DTI) was performed in 24 patients with brain abscess and Staphylococcus aureus-treated as well as nontreated Jurket cell lines (at 4 time points: 1, 24, 48, and 72 hours). Neuroinflammatory molecules were quantified from the brain abscess cavity aspirate of the patients as well as from the heat-killed S aureus-treated and nontreated cell lines and correlated with DTI measures.
resultsThe DTI-derived FA strongly correlated with the presence of neuroinflammatory molecules in the pus as well as in S aureus-treated cell lines; no such correlation was observed in nontreated cell lines.
conclusionsThese data indicate that neuroinflammatory molecules confer high diffusion anisotropy inside the brain abscess cavity. We propose that increased FA reflects upregulated inflammatory response in brain abscess.
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