ArticleAmerican journal of respiratory and critical care medicine2008
Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer.
Article in American journal of respiratory and critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers.Cancer prevention research (Philadelphia, Pa.) · 2019Trial
- Oral iloprost improves endobronchial dysplasia in former smokers.Cancer prevention research (Philadelphia, Pa.) · 2011Trial
- Epstein-Barr Virus Infection in Lung Cancer: Insights and Perspectives.Pathogens (Basel, Switzerland) · 2022Review
- 2020 Innovation-Based Optimism for Lung Cancer Outcomes.The oncologist · 2021Review
- Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia.Cancer research · 2018Article
- Clinical Utility of Chromosomal Aneusomy in Individuals at High Risk of Lung Cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2017Article
- Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Preinvasive Endobronchial Lesions: Lung Cancer Precursors and Risk Markers?American journal of respiratory and critical care medicine · 2015Article
- Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Lung cancer chemoprevention: current status and future prospects.Nature reviews. Clinical oncology · 2013Review
- SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling.Journal of molecular medicine (Berlin, Germany) · 2013Article
- Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation.Journal of cellular physiology · 2012Article
- [Preneoplastic lesions of pulmonary carcinoma].Der Pathologe · 2011Review
- Progressive endobronchial premalignancy: marked by original CIN.American journal of respiratory and critical care medicine · 2011Article
- Chemoprevention of murine lung cancer by gefitinib in combination with prostacyclin synthase overexpression.Lung cancer (Amsterdam, Netherlands) · 2010Article
- Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer.American journal of respiratory and critical care medicine · 2010Article
- The relationship between the presence of chromosomal instability and prognosis of squamous cell carcinoma of the lung: fluorescence in situ hybridization analysis of paraffin-embedded tissue from 47 Korean patients.Journal of Korean medical science · 2010Article
- The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Natural history of bronchial preinvasive lesions.Cancer metastasis reviews · 2010Review
- Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer.PloS one · 2009Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
rationaleThe development of lung cancer (LC) is accompanied by field changes in the airway mucosa that may have prognostic importance.
objectivesTo compare patients with prevalent LC to control subjects regarding their histologic dysplasia scores and chromosomal aneusomy as measured by fluorescence in situ hybridization (FISH).
methodsThe most advanced bronchial histology lesion was assessed from each of 44 LC cases and 90 cancer-free control subjects using a four-color FISH probe set encompassing the chromosome 6 centromere, 5p15.2, 7p12 (epidermal growth factor receptor), and 8q24 v-myc myelocytomatosis viral oncogene homolog (MYC) sequences. Histology grades were coded as dysplasia (moderate or severe) or carcinoma in situ (CIS). MEASUREMENTS AND MAIN
resultsCIS was the highest histologic grade for 32 subjects, and dysplasia was the highest grade for 102 subjects (54 moderate, 48 severe). Chromosomal aneusomy was seen in 64% of the LC cases, but in only 31% of the control subjects (odds ratio [OR], 4.68; 95% confidence interval [CI]. 1.97-11.04). Among those with any level of dysplasia, the OR for positive FISH and LC was 2.28 (95% CI, 0.75-6.86). Among those with CIS, the OR for positive FISH and LC was 5.84 (95% CI, 1.31-26.01).
conclusionsChromosomal aneusomy is associated with LC. Prospective examination of aneusomy as a precursor lesion that predicts LC is needed.
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