Evidence map›Paper›PMID 17989340›Full record

ArticleClinical and vaccine immunology : CVI2008

Modulation of type 1 diabetes susceptibility by tumor necrosis factor alpha -308 G/A and lymphotoxin alpha +249 A/G haplotypes and lack of linkage disequilibrium with predisposing DQB1-DRB1 haplotypes in Bahraini patients.

Mouna Stayoussef, Fayza A Al-Jenaidi, Abduljabbar Al-Abbasi, Khadija Al-Ola, Haya Khayyat, Touhami Mahjoub, Wassim Y Almawi

Abstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mouna StayoussefUniversity of Monastir, Monastir, Tunisia.
Fayza A Al-Jenaidi
Abduljabbar Al-Abbasi
Khadija Al-Ola
Haya Khayyat
Touhami Mahjoub
Wassim Y Almawi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor necrosis factor alpha (TNF-alpha) -308 G/A and lymphotoxin alpha (LTalpha) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LTalpha +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-alpha/LTalpha alleles and susceptible/protective DRB1-DQB1 haplotypes. TNF-alpha/LTalpha T1DM-susceptible (-308G/+249G) and protective (-308G/+249A) haplotypes were identified.

Indexed as

Genetic Predisposition to DiseaseLinkage DisequilibriumAdolescentAdultBahrainChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGene FrequencyGenotypeHaplotypesHLA-DQ AntigensHLA-DQ beta-ChainsHumansLymphotoxin-alphaHLA-DQ AntigensHLA-DQbeta antigenHLA-DQ beta-ChainsLymphotoxin-alphaTumor Necrosis Factor-alpha

Identifiers

PMID17989340
PMCPMC2238059

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.