ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Reconfiguration of a vertebrate motor network: specific neuron recruitment and context-dependent synaptic plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord.iScience · 2025Article
- Excitatory and Inhibitory Descending Commissural Interneurons Differentially Integrate Supraspinal and Segmental Sensory Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A Scalar Poincaré Map for Anti-phase Bursting in Coupled Inhibitory Neurons With Synaptic Depression.Frontiers in applied mathematics and statistics · 2022Article
- From decision to action: Detailed modelling of frog tadpoles reveals neuronal mechanisms of decision-making and reproduces unpredictable swimming movements in response to sensory signals.PLoS computational biology · 2021Article
- Modeling Post-Scratching Locomotion with Two Rhythm Generators and a Shared Pattern Formation.Biology · 2021Article
- The Spinal Control of Backward Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Contributions of h- and NaFrontiers in cellular neuroscience · 2021Article
- Neurotransmitters and Motoneuron Contacts of Multifunctional and Behaviorally Specialized Turtle Spinal Cord Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Nervous mechanisms of locomotion in different directions.Current opinion in physiology · 2019Article
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- Stimulation of Single, Possible CHX10 Hindbrain Neurons Turns Swimming On and Off in YoungFrontiers in cellular neuroscience · 2019Article
- A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times.The Journal of physiology · 2018Article
- Article
- Article
- To swim or not to swim: A population-level model of Xenopus tadpole decision making and locomotor behaviour.Bio Systems · 2017Article
- Zebrafish transgenic constructs label specific neurons in Xenopus laevis spinal cord and identify frog V0v spinal neurons.Developmental neurobiology · 2017Article
- The modulation of two motor behaviors by persistent sodium currents inJournal of neurophysiology · 2017Article
- Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion.eLife · 2017Article
- Shared Components of Rhythm Generation for Locomotion and Scratching Exist Prior to Motoneurons.Frontiers in neural circuits · 2017Article
- The central pattern generator underlying swimming in Dendronotus iris: a simple half-center network oscillator with a twist.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor networks typically generate several related output patterns or gaits where individual neurons may be shared or recruited between patterns. We investigate how a vertebrate locomotor network is reconfigured to produce a second rhythmic motor pattern, defining the detailed pattern of neuronal recruitment and consequent changes in the mechanism for rhythm generation. Hatchling Xenopus tadpoles swim if touched, but when held make slower, stronger, struggling movements. In immobilized tadpoles, a brief current pulse to the skin initiates swimming, whereas 40 Hz pulses produce struggling. The classes of neurons active during struggling are defined using whole-cell patch recordings from hindbrain and spinal cord neurons during 40 Hz stimulation of the skin. Some motoneurons and inhibitory interneurons are active in both swimming and struggling, but more neurons are recruited within these classes during struggling. In addition, and in contrast to a previous study, we describe two new classes of excitatory interneuron specifically recruited during struggling and define their properties and synaptic connections. We then explore mechanisms that generate struggling by building a network model incorporating these new neurons. As well as the recruitment of new neuron classes, we show that reconfiguration of the locomotor network to the struggling central pattern generator (CPG) reveals a context-dependent synaptic depression of reciprocal inhibition: the result of increased inhibitory neuron firing frequency during struggling. This provides one possible mechanism for burst termination not seen in the swimming CPG. The direct demonstration of depression in reciprocal inhibition confirms a key element of Brown's (1911) hypothesis for locomotor rhythmogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.