ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Activity-dependent synaptic plasticity in retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- AMPAR dysregulation in microglia drives vascular pathology in diabetic retinopathy via the P2X7R/NLRP3/IL-1β pathway.Journal of translational medicine · 2026Article
- Calcium-permeable AMPA receptors on AII amacrine cells mediate sustained signaling in the On-pathway of the primate retina.Cell reports · 2022Article
- Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells.Journal of neurophysiology · 2021Article
- Ocular Hypertension Drives Remodeling of AMPA Receptors in Select Populations of Retinal Ganglion Cells.Frontiers in synaptic neuroscience · 2020Article
- Elevated Pressure Increases CaFrontiers in cellular neuroscience · 2018Article
- Trafficking of calcium-permeable and calcium-impermeable AMPA receptors in nucleus accumbens medium spiny neurons co-cultured with prefrontal cortex neurons.Neuropharmacology · 2017Article
- Kainate receptors mediate synaptic input to transient and sustained OFF visual pathways in primate retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A protein synthesis-dependent mechanism sustains calcium-permeable AMPA receptor transmission in nucleus accumbens synapses during withdrawal from cocaine self-administration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Spatial organization of AMPAR subtypes in ON RGCs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Down-regulation of the RNA editing enzyme ADAR2 contributes to RGC death in a mouse model of glaucoma.PloS one · 2014Article
- Molecular mechanisms underlying activity-dependent AMPA receptor cycling in retinal ganglion cells.Molecular and cellular neurosciences · 2013Article
- Directional summation in non-direction selective retinal ganglion cells.PLoS computational biology · 2013Article
- Light-induced plasticity of synaptic AMPA receptor composition in retinal ganglion cells.Neuron · 2012Article
- Light-evoked synaptic activity of retinal ganglion and amacrine cells is regulated in developing mouse retina.The European journal of neuroscience · 2011Article
- Calcium-permeable AMPA receptors in the retina.Frontiers in molecular neuroscience · 2011Article
- Dendritic calcium signaling in ON and OFF mouse retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Characterization of the transcripts and protein isoforms for cytoplasmic polyadenylation element binding protein-3 (CPEB3) in the mouse retina.BMC molecular biology · 2009Article
- Functional stability of retinal ganglion cells after degeneration-induced changes in synaptic input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Presynaptic type III neuregulin1-ErbB signaling targets {alpha}7 nicotinic acetylcholine receptors to axons.The Journal of cell biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
At many excitatory synapses, AMPA-type receptors (AMPARs) are not statically situated in the membrane, but undergo continuous rounds of endocytosis and exocytosis, referred to as rapid cycling. AMPAR cycling is believed to play a role in certain forms of synaptic plasticity, but the link between cycling and synaptic function is not well understood. We have previously demonstrated that AMPARs cycle in neurons of the inner retina, including amacrine and ganglion cells, and that cycling is inhibited by synaptic activity. Recording from cultured neurons and ON ganglion cells in the flat-mount retina, we now show that rapid cycling is primarily, perhaps exclusively, restricted to AMPARs that contain the GluR2 subunit, and that cycle is confined to extrasynaptic receptors. We also demonstrate a form of plasticity at the ON bipolar cell-ON ganglion cell synapse, whereby synaptic quiescence drives a change in the composition of AMPARs from predominantly GluR2-containing to GluR2-lacking. Finally, we provide evidence linking synaptic receptor composition and cycling, showing that disruption of cycling leads increases the number of GluR2-containing receptors in the ON bipolar-ON ganglion cell synapse. We propose that cycling lowers the number of GluR2-containing receptors at the surface and, consequently, within the synapse. After increased levels of synaptic activity, cycling ceases, and all GluR2-containing receptors are free to go to the surface, where they can be delivered to synapses. Our results suggest that by regulating the cycling of AMPARs, ambient light can modulate the composition of synaptic receptors in ON ganglion cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.