ArticleGenome research2007
Hitchhiking effects of recurrent beneficial amino acid substitutions in the Drosophila melanogaster genome.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 113 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
113 citing papers in PubMed, 206 citations in OpenAlex.
- Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein.PLoS genetics · 2026Article
- Epistasis among clustered lineage-specific adaptive amino acid substitutions in the Drosophila Trio protein.bioRxiv : the preprint server for biology · 2025Article
- Shared evolutionary processes shape landscapes of genomic variation in the great apes.Genetics · 2024Article
- Widespread Deviant Patterns of Heterozygosity in Whole-Genome Sequencing Due to Autopolyploidy, Repeated Elements, and Duplication.Genome biology and evolution · 2023Article
- Shared evolutionary processes shape landscapes of genomic variation in the great apes.bioRxiv : the preprint server for biology · 2023Article
- CEGA: a method for inferring natural selection by comparative population genomic analysis across species.Genome biology · 2023Article
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- African Suid Genomes Provide Insights into the Local Adaptation to Diverse African Environments.Molecular biology and evolution · 2022Article
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- Revisiting the notion of deleterious sweeps.Genetics · 2021Article
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- Molecular population genetics of Sex-lethal (Sxl) in the Drosophila melanogaster species group: a locus that genetically interacts with Wolbachia pipientis in Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- A novel family of secreted insect proteins linked to plant gall development.Current biology : CB · 2021Article
- Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice andGenome research · 2021Article
- Background Selection Does Not Mimic the Patterns of Genetic Diversity Produced by Selective Sweeps.Genetics · 2020Article
- Estimating the genome-wide contribution of selection to temporal allele frequency change.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Population Genomics on the Fly: Recent Advances in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2020Review
- The Effects on Neutral Variability of Recurrent Selective Sweeps and Background Selection.Genetics · 2019Article
- Impacts of Recurrent Hitchhiking on Divergence and Demographic Inference in Drosophila.Genome biology and evolution · 2018Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several recent studies have estimated that a large fraction of amino acid divergence between species of Drosophila was fixed by positive selection, using statistical approaches based on the McDonald-Kreitman test. However, little is known about associated selection coefficients of beneficial amino acid mutations. Recurrent selective sweeps associated with adaptive substitutions should leave a characteristic signature in genome variability data that contains information about the frequency and strength of selection. Here, I document a significant negative correlation between the level and the frequency of synonymous site polymorphism and the rate of protein evolution in highly recombining regions of the X chromosome of D. melanogaster. This pattern is predicted by recurrent adaptive protein evolution and suggests that adaptation is an important determinant of patterns of neutral variation genome-wide. Using a maximum likelihood approach, I estimate the product of the rate and strength of selection under a recurrent genetic hitchhiking model, lambda2N(e)s approximately 3 x 10(-8). Using an approach based on the McDonald-Kreitman test, I estimate that approximately 50% of divergent amino acids were driven to fixation by positive selection, implying that beneficial amino acid substitutions are of weak effect on average, on the order of 10(-5) (i.e., 2N(e)s approximately 40). Two implications of these results are that most adaptive substitutions will be difficult to detect in genome scans of selection and that population size (and genetic drift) may be an important determinant of the evolutionary dynamics of protein adaptation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.