ArticleGenome research2007
Significant gene content variation characterizes the genomes of inbred mouse strains.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 101 citations in OpenAlex.
- Do all mice smell the same? Chemosensory cues from inbred and wild mouse strains elicit stereotypic sensory representations in the accessory olfactory bulb.BMC biology · 2021Article
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Mouse protein coding diversity: What's left to discover?PLoS genetics · 2019Review
- Genetic basis of voluntary water consumption in two divergently selected strains of inbred mice.Veterinary medicine and science · 2019Article
- The Genome of C57BL/6J "Eve", the Mother of the Laboratory Mouse Genome Reference Strain.G3 (Bethesda, Md.) · 2019Article
- Genome-wide analysis reveals differential selection involved with copy number variation in diverse Chinese Cattle.Scientific reports · 2017Article
- Analysis of Copy Number Variation in the Abp Gene Regions of Two House Mouse Subspecies Suggests Divergence during the Gene Family Expansions.Genome biology and evolution · 2017Article
- The Mouse Universal Genotyping Array: From Substrains to Subspecies.G3 (Bethesda, Md.) · 2015Article
- Divergence patterns of genic copy number variation in natural populations of the house mouse (Mus musculus domesticus) reveal three conserved genes with major population-specific expansions.Genome research · 2015Article
- Genomic copy number variation in Mus musculus.BMC genomics · 2015Article
- The landscape of somatic chromosomal copy number aberrations in GEM models of prostate carcinoma.Molecular cancer research : MCR · 2015Article
- Effect of crossing C57BL/6 and FVB mouse strains on basal cytokine expression.Mediators of inflammation · 2015Article
- Connecting Anxiety and Genomic Copy Number Variation: A Genome-Wide Analysis in CD-1 Mice.PloS one · 2015Article
- Detection of copy number variations and their effects in Chinese bulls.BMC genomics · 2014Article
- Increased genomic integrity of an improved protein-based mouse induced pluripotent stem cell method compared with current viral-induced strategies.Stem cells translational medicine · 2014Article
- Genome-wide copy number variant discovery in dogs using the CanineHD genotyping array.BMC genomics · 2014Article
- Identification of structural variation in mouse genomes.Frontiers in genetics · 2014Review
- The molecular evolutionary dynamics of the vomeronasal receptor (class 1) genes in primates: a gene family on the verge of a functional breakdown.Frontiers in neuroanatomy · 2014Review
- Copy number variants and selective sweeps in natural populations of the house mouse (Mus musculus domesticus).Frontiers in genetics · 2014Review
- Genome-wide copy number variations in Oryza sativa L.BMC genomics · 2013Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contribution to genetic diversity of genomic segmental copy number variations (CNVs) is less well understood than that of single-nucleotide polymorphisms (SNPs). While less frequent than SNPs, CNVs have greater potential to affect phenotype. In this study, we have performed the most comprehensive survey to date of CNVs in mice, analyzing the genomes of 42 Mouse Phenome Consortium priority strains. This microarray comparative genomic hybridization (CGH)-based analysis has identified 2094 putative CNVs, with an average of 10 Mb of DNA in 51 CNVs when individual mouse strains were compared to the reference strain C57BL/6J. This amount of variation results in gene content that can differ by hundreds of genes between strains. These genes include members of large families such as the major histocompatibility and pheromone receptor genes, but there are also many singleton genes including genes with expected phenotypic consequences from their deletion or amplification. Using a whole-genome association analysis, we demonstrate that complex multigenic phenotypes, such as food intake, can be associated with specific copy number changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.