Evidence map›Paper›PMID 17989087›Full record

ArticleNucleic acids research2008

The Stanford Tissue Microarray Database.

Robert J Marinelli, Kelli Montgomery, Chih Long Liu, Nigam H Shah, Wijan Prapong, Michael Nitzberg, Zachariah K Zachariah, Gavin J Sherlock, Yasodha Natkunam, Robert B West and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  17. Machine Learning Methods for Histopathological Image Analysis.Computational and structural biotechnology journal · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Robert J MarinelliDepartment of Biochemistry, Stanford University School of Medicine, Howard Hughes Medical Institute, Stanford, CA, USA. bobm@stanford.edu
Kelli Montgomery
Chih Long Liu
Nigam H Shah
Wijan Prapong
Michael Nitzberg
Zachariah K Zachariah
Gavin J Sherlock
Yasodha Natkunam
Robert B West
Matt van de Rijn
Patrick O Brown
Catherine A Ball
Stanford University · USHoward Hughes Medical Institute · US

Funding

STANFORD COMPOSITE(RMI)U54HG004028 · NHGRI · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2005 to 2014
$36.2M
GENE EXPRESSION IN CANCER BY MICROARRAY HYBRIDIZATIONR01CA077097 · NCI · STANFORD UNIVERSITY · PI BROWN, PATRICK O. · 1997 to 2010
$8.7M
NCI NIH HHS 5R01 CA77097NCI NIH HHS R01 CA077097NHGRI NIH HHS U54 HG004028
6 · The paper itself

Abstract

The Stanford Tissue Microarray Database (TMAD; http://tma.stanford.edu) is a public resource for disseminating annotated tissue images and associated expression data. Stanford University pathologists, researchers and their collaborators worldwide use TMAD for designing, viewing, scoring and analyzing their tissue microarrays. The use of tissue microarrays allows hundreds of human tissue cores to be simultaneously probed by antibodies to detect protein abundance (Immunohistochemistry; IHC), or by labeled nucleic acids (in situ hybridization; ISH) to detect transcript abundance. TMAD archives multi-wavelength fluorescence and bright-field images of tissue microarrays for scoring and analysis. As of July 2007, TMAD contained 205 161 images archiving 349 distinct probes on 1488 tissue microarray slides. Of these, 31 306 images for 68 probes on 125 slides have been released to the public. To date, 12 publications have been based on these raw public data. TMAD incorporates the NCI Thesaurus ontology for searching tissues in the cancer domain. Image processing researchers can extract images and scores for training and testing classification algorithms. The production server uses the Apache HTTP Server, Oracle Database and Perl application code. Source code is available to interested researchers under a no-cost license.

Indexed as

Databases, GeneticImmunohistochemistryIn Situ HybridizationTissue Array AnalysisHumansInternetProteinsRNA, MessengerSoftwareUser-Computer InterfaceProteinsRNA, Messenger

Identifiers

PMID17989087
PMCPMC2238948
OpenAlexW1985098533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.