ArticleVirology2008
Capripoxvirus tissue tropism and shedding: A quantitative study in experimentally infected sheep and goats.
Article in Virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 1 of them a synthesis that pooled it.
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Who cites it
143 citing papers in PubMed, 1 synthesis or guideline pooled it, 294 citations in OpenAlex.
- A review: Lumpy skin disease and its emergence in India.Veterinary research communications · 2020Pooled it
- Three thousand five hundred years of sheeppox virus evolution inferred from archaeological and codicological genomes.Science advances · 2026Article
- Genetic Characterisation and Risk Factors Associated With Capripoxvirus Outbreaks Among Small Ruminants in Uganda, 2021-2022.Veterinary medicine and science · 2026Article
- Development and diagnostic evaluation of a reverse passive latex agglutination test for rapid field detection of lumpy skin disease virus antigen.Veterinary research communications · 2026Article
- Comparison of multiple antigens for use in indirect ELISAs for detection of anti-capripoxvirus antibodies in sheep, goats, and cattle.Journal of clinical microbiology · 2026Article
- First complete genome of a fowlpox virus isolated in Bangladesh reveals Asian lineage and clade A1.Microbiology spectrum · 2026Article
- Article
- Molecular detection and isolation of Lumpy Skin Disease Virus from outbreak cases in Ilubabor Zone, Oromia, Ethiopia.BMC microbiology · 2026Article
- Demonstration of the pathogenicity of LSDV pendik strain in cattle.Archives of virology · 2026Article
- A GTPV-Based Murine Model Recapitulating Key Features of Lumpy Skin Disease for Preclinical Vaccine Evaluation.Animals : an open access journal from MDPI · 2026Article
- Cell death modulation dictates tissue-specific tropism of lumpy skin disease virus.PLoS pathogens · 2026Article
- Comparison of whole genome sequencing approaches for Capripox viruses.BMC genomics · 2026Article
- Epidemiology and molecular characterization of lumpy skin disease virus in cattle in the Poro Region of Ivory Coast.Frontiers in veterinary science · 2026Article
- Article
- Lumpy Skin Disease Virus Infected Calves Showing Multisystemic Vasculitis on Postmortem Examination: A Summary of Six Cases.Transboundary and emerging diseases · 2026Article
- Development and evaluation of a multiplex PCR-based dual-platform targeted sequencing framework for precise differentiation of lumpy skin disease virus.Frontiers in microbiology · 2026Article
- Production of the Bakırköy strain of sheeppox vaccine virus in spinner flasks using an alternative method with Cytodex 1 microcarriers on Vero cells.BMC biotechnology · 2025Article
- An Evaluation of the Efficacy of Four Currently Used Sheep Pox Vaccines Against a Contemporary Virulent Strain.Vaccines · 2025Article
- Genetic Characterization of the First Case of Lumpy Skin Disease in Singapore, 2022.Veterinary sciences · 2025Article
- Integrating Serological and Genomic Data to Elucidate Lumpy Skin Disease Virus Diversity in Cattle from Bangladesh.Viruses · 2025Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sheeppox virus and goatpox virus cause systemic disease in sheep and goats that is often associated with high morbidity and high mortality. To increase understanding of the pathogenesis of these diseases, we undertook quantitative time-course studies in sheep and goats following intradermal inoculation of Nigerian sheeppox virus or Indian goatpox virus in their respective homologous hosts. Viremia, determined by virus isolation and real-time PCR, cleared within 2 to 3 weeks post inoculation. Peak shedding of viral DNA and infectious virus in nasal, conjunctival and oral secretions occurred between 10 and 14 days post inoculation, and persisted at low levels for up to an additional 3 to 6 weeks. Although gross lesions developed in multiple organ systems, highest viral titers were detected in skin and in discrete sites within oronasal tissues and gastrointestinal tract. The temporal distribution of infectious virus and viral DNA in tissues suggests an underlying pathogenesis that is similar to smallpox and monkeypox where greatest viral replication occurs in the skin. Our data demonstrate that capripoxvirus infections in sheep and goats provide additional and convenient models which are suitable not only for evaluation of poxvirus-specific vaccine concepts and therapeutics, but also study of poxvirus-host interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.