Evidence map›Paper›PMID 17988702›Full record

ArticleVirology2008

Protection of macaques against AIDS with a live attenuated SHIV vaccine is of finite duration.

Anil Kumar, Zhenqian Liu, Darlene Sheffer, Marilyn Smith, Dinesh K Singh, Shilpa Buch, Opendra Narayan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Anil KumarDivision of Pharmacology, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA. kumaran@umkc.edu
Zhenqian Liu
Darlene Sheffer
Marilyn Smith
Dinesh K Singh
Shilpa Buch
Opendra Narayan
University of Kansas · USUniversity of Missouri–Kansas City · USWinston-Salem State University · US

Funding

YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
XRAY CRYSTALLOGRAPHY CORE (JANUARY 1 - JUNE 30, 2005)P20RR016443 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI VINES, CHARLOTTE M · 2001 to 2010
$21.3M
Efffects of opiate virus/host response in SHIV/macaqueR01DA015013 · NIDA · UNIVERSITY OF MISSOURI KANSAS CITY · PI KUMAR, ANIL · 2001 to 2011
$3.1M
Safety and Efficacy of SHIV Vaccine in MacaquesR01AI051220 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NARAYAN, OPENDRA · 2002 to 2006
$3.0M
MUCOSALLY TRANSMITTED PATHOGENIC SHIV, DISEASE/VACCINER01RR006753 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NARAYAN, OPENDRA · 1991 to 2003
$2.7M
NEUROPATHOGENESIS AND THERAPY OF SHIV-KU INFECTIONR01NS040238 · NINDS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NARAYAN, OPENDRA · 1999 to 2003
$2.4M
Methamphetamine and AIDS in a Non-Human Primate ModelR01DA025011 · NIDA · UNIVERSITY OF MISSOURI KANSAS CITY · PI KUMAR, ANIL · 2008 to 2014
$1.8M
NCRR NIH HHS P20 RR016443NCRR NIH HHS P20RR016443NCRR NIH HHS P51 RR000165NCRR NIH HHS P51RR000165NCRR NIH HHS R01 RR006753NCRR NIH HHS RR006753NIAID NIH HHS AI051220NIAID NIH HHS R01 AI051220NIDA NIH HHS DA015013NIDA NIH HHS R01 DA015013NIDA NIH HHS R01 DA025011NINDS NIH HHS NS040238NINDS NIH HHS R01 NS040238
6 · The paper itself

Abstract

Using background data that live vaccines against several viral pathogens are effective in inducing life-long protection against disease, we undertook studies in macaques to determine the duration of protection that two live SHIV vaccines could induce against AIDS. Earlier studies had established that macaques immunized once with a live vaccine and challenged 6 months later were protected, and that other macaques given two sequential inoculations of live vaccines were protected for at least 1 year. Protection was associated with persistence of the vaccine viruses. In this study, we sought to determine whether the duration of protection in macaques given a single inoculation of replication competent live vaccines would extend beyond 3 years. Two groups of four rhesus macaques were inoculated with two live SHIV vaccines, respectively. The viruses replicated transiently in all animals but at the 3-year time point, PCR analysis of PBMC did not detect DNA of either virus in any of the animals, and all were negative for CMI responses in the blood. All 8 animals succumbed to disease when challenged with pathogenic viruses.

Indexed as

AIDS VaccinesAnimalsCD4 Lymphocyte CountHIV-1HIV InfectionsMacaca mulattaRNA, ViralSAIDS VaccinesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusTime FactorsVaccinationVaccines, AttenuatedAIDS VaccinesRNA, ViralSAIDS VaccinesVaccines, Attenuated

Identifiers

PMID17988702
PMCPMC2757128
OpenAlexW2083257593

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.