ArticlePLoS biology2007
Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 403 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
403 citing papers in PubMed.
- Allelic gene conversion softens selective sweeps.Genetics · 2026Article
- Repeated cases of allopatric divergence and secondary contact in cattail (Typha) speciation.Heredity · 2026Article
- Calibrating and documenting host-switching and evolution of incompatibility loci for two closely related Wolbachia clades.Genetics · 2026Article
- MKado: a toolkit for McDonald-Kreitman tests of natural selection.G3 (Bethesda, Md.) · 2026Article
- Germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes.Heredity · 2026Article
- An X-linked sex determination mechanism in cannabis and hop.Nature communications · 2026Article
- Using pangenome variation graphs to improve mutation detection in a large DNA virus.Microbial genomics · 2026Article
- Influence of geography, seasonality and experimental selection on Chironomus riparius recombination rates.BMC genomics · 2026Article
- The birth, death, and evolutionary compensation of uORFs in Drosophila.Nucleic acids research · 2026Article
- Uniform bacterial genetic diversity along the gut.Nature communications · 2026Article
- Calibrating and documenting host-switching and evolution of incompatibility loci for two closely relatedbioRxiv : the preprint server for biology · 2026Article
- On ARGs, pedigrees, and genetic relatedness matrices.Genetics · 2026Article
- An X-linked sex determination mechanism in cannabis and hop.bioRxiv : the preprint server for biology · 2025Article
- On ARGs, pedigrees, and genetic relatedness matrices.bioRxiv : the preprint server for biology · 2025Article
- Exploring the genetics of social behaviour in C. calcarata.Scientific reports · 2025Article
- Two major-effect loci influence interspecific mating in females of the sibling species, Drosophila simulans and D. sechellia.G3 (Bethesda, Md.) · 2025Article
- The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence.Science advances · 2024Article
- Whole genome resequencing-based analysis of plateau adaptation in Meiren yak (Animal biotechnology · 2024Article
- Chromosome-scale genome of the polyphagous pest Anastrepha ludens (Diptera: Tephritidae) provides insights on sex chromosome evolution in Anastrepha.G3 (Bethesda, Md.) · 2024Article
- Polymorphism-Aware Models in RevBayes: Species Trees, Disentangling Balancing Selection, and GC-Biased Gene Conversion.Molecular biology and evolution · 2024Article
343 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
The population genetic perspective is that the processes shaping genomic variation can be revealed only through simultaneous investigation of sequence polymorphism and divergence within and between closely related species. Here we present a population genetic analysis of Drosophila simulans based on whole-genome shotgun sequencing of multiple inbred lines and comparison of the resulting data to genome assemblies of the closely related species, D. melanogaster and D. yakuba. We discovered previously unknown, large-scale fluctuations of polymorphism and divergence along chromosome arms, and significantly less polymorphism and faster divergence on the X chromosome. We generated a comprehensive list of functional elements in the D. simulans genome influenced by adaptive evolution. Finally, we characterized genomic patterns of base composition for coding and noncoding sequence. These results suggest several new hypotheses regarding the genetic and biological mechanisms controlling polymorphism and divergence across the Drosophila genome, and provide a rich resource for the investigation of adaptive evolution and functional variation in D. simulans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.