ArticlePLoS biology2007
A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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111 citing papers in PubMed.
- Disruption of small RNAs and mechanistic variation in Segregation Distorter: A sperm-killing drive system in Drosophila melanogaster.PLoS genetics · 2026Article
- The evolutionary genomics of meiotic drive.Molecular biology and evolution · 2026Article
- Recurrent expansion and rapid evolution of the Drosophilid RNAi pathway in testis.bioRxiv : the preprint server for biology · 2025Article
- Phylogenetic Relatedness Does not Predict Patterns of Parallel Transcriptome Adaptation in Drosophila.Genome biology and evolution · 2025Article
- Intrinsically weak sex chromosome drive through sequential asymmetric meiosis.Science advances · 2025Article
- Testis- and ovary-expressed polo-like kinase transcripts and gene duplications affect male fertility when expressed in the Drosophila melanogaster germline.G3 (Bethesda, Md.) · 2025Article
- Running the gauntlet: challenges to genome integrity in spermiogenesis.Nucleus (Austin, Tex.) · 2024Review
- Comparative Genomics Supports Ecologically Induced Selection as a Putative Driver of Banded Penguin Diversification.Molecular biology and evolution · 2024Article
- Non-Mendelian transmission of X chromosomes: mechanisms and impact on sex ratios and population dynamics in different breeding systems.Biochemical Society transactions · 2024Review
- Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter.PLoS genetics · 2024Article
- The roles of gene duplications in the dynamics of evolutionary conflicts.Proceedings. Biological sciences · 2024Review
- New perspectives on the causes and consequences of male meiotic drive.Current opinion in genetics & development · 2023Review
- Genetic conflict and the origin of multigene families: implications for sex chromosome evolution.Proceedings. Biological sciences · 2023Review
- The suppression of a selfish genetic element increases a male's mating success in a fly.Ecology and evolution · 2023Article
- Proliferation and dissemination of killer meiotic drive loci.Current opinion in genetics & development · 2023Review
- Regulatory logic of endogenous RNAi in silencing de novo genomic conflicts.PLoS genetics · 2023Article
- Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans.PLoS biology · 2023Article
- Derepression of Y-linked multicopy protamine-like genes interferes with sperm nuclear compaction inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Meiotic drive adaptive testes enlargement during early development in the stalk-eyed fly.Biology letters · 2022Article
51 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Sex ratio distortion (sex-ratio for short) has been reported in numerous species such as Drosophila, where distortion can readily be detected in experimental crosses, but the molecular mechanisms remain elusive. Here we characterize an autosomal sex-ratio suppressor from D. simulans that we designate as not much yang (nmy, polytene chromosome position 87F3). Nmy suppresses an X-linked sex-ratio distorter, contains a pair of near-perfect inverted repeats of 345 bp, and evidently originated through retrotransposition from the distorter itself. The suppression is likely mediated by sequence homology between the suppressor and distorter. The strength of sex-ratio is greatly enhanced by lower temperature. This temperature sensitivity was used to assign the sex-ratio etiology to the maturation process of the Y-bearing sperm, a hypothesis corroborated by both light microscope observations and ultrastructural studies. It has long been suggested that an X-linked sex-ratio distorter can evolve by exploiting loopholes in the meiotic machinery for its own transmission advantage, which may be offset by other changes in the genome that control the selfish distorter. Data obtained in this study help to understand this evolutionary mechanism in molecular detail and provide insight regarding its evolutionary impact on genomic architecture and speciation.
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