ReviewJournal of the National Medical Association2007
Leiomyomata uteri: hormonal and molecular determinants of growth.
Review in Journal of the National Medical Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study.Frontiers in endocrinology · 2023Pooled it
- Lower prevalence of non-cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility.Fertility and sterility · 2019Trial
- Decoding uterine (dys)function in fibroids through multimodal assessment of functional determinants: a systematic review and meta-analysis.Human reproduction open · 2025Review
- Microvascular flow imaging of fibroids: A prospective pilot study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Genetic Contribution of the Adrenergic, Cholinergic, and Serotonergic Systems to Leiomyoma Development and Treatment.International journal of molecular and cellular medicine · 2023Article
- Emerging Roles of Long Non-coding RNAs in Uterine Leiomyoma Pathogenesis: a Review.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Micronutrient and Trace Element Levels in Serum of Women With Uterine Fibroids in Lagos.Cureus · 2021Article
- Article
- Association of HOTAIR gene polymorphisms and haplotypes with uterine leiomyoma susceptibility in southeast of Iran.Molecular biology reports · 2019Article
- Adlay (Molecules (Basel, Switzerland) · 2019Article
- Natural History of Uterine Fibroids: A Radiological Perspective.Current obstetrics and gynecology reports · 2018Review
- Chronic Inflammation May Enhance Leiomyoma Development by the Involvement of Progenitor Cells.Stem cells international · 2018Article
- Removal of uterine fibroids by mini-laparotomy technique in women who wish to preserve their uterus and fertility.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2016Article
- Circulating Sex Hormones and Risk of Uterine Fibroids: Study of Women's Health Across the Nation (SWAN).The Journal of clinical endocrinology and metabolism · 2016Article
- Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Müllerian duct mesenchyme-derived myometria.Molecular human reproduction · 2014Article
- Effect of Isopropanolic Cimicifuga racemosa Extract on Uterine Fibroids in Comparison with Tibolone among Patients of a Recent Randomized, Double Blind, Parallel-Controlled Study in Chinese Women with Menopausal Symptoms.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Biomarkers in uterine leiomyoma.Fertility and sterility · 2013Review
- Validation of the aging hen (Gallus gallus domesticus) as an animal model for uterine leiomyomas.Biology of reproduction · 2012Article
- Functional gene polymorphism of matrix metalloproteinase-1 is associated with benign hyperplasia of myo- and endometrium in the Russian population.Genetic testing and molecular biomarkers · 2012Article
- The genetic bases of uterine fibroids; a review.Journal of reproduction & infertility · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review the available English literature that examines the biology of leiomyoma uteri in African-American women and other ethnic groups. Factors that influence the growth and development of leiomyomas are examined to understand the basis for larger myomas in African-American women.
designLiterature review of 176 articles regarding the pathobiology of leiomyoma in various ethnic groups.
resultsThe initiating factor(s) associated with the transformation of a normal myometrial cell into a leiomyoma cell remain(s) to be determined. Epidemiological studies have confirmed that different ethnic groups develop leiomyomas. However, African-American ethnicity is a risk factor for the development of leiomyomas. Studies have examined diet, genetics, hormonal, growth, enzymatic and molecular determinants of myoma biology, with critical advances in some of these areas. The best radiological tools to identify and monitor leiomyomas are ultrasonography and/or magnetic resonance imaging. Evidence supports progesterone and growth factors (e.g., transforming growth factor-B), have significant impact on the development of leiomyomas.
conclusionsEarly monitoring and intervention should become standard for African-American women who are at greater risk for developing leiomyomas. There are plausible biological mechanisms that explain the predisposition for developing larger leiomyomas in African-American women as compared with other ethnic groups.
Indexed as
Identifiers
17987921PMC2574407W1523140553What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.