ArticleNeurochemical research2008
Species comparison of adenosine receptor subtypes in brain and testis.
Article in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Mitochondrial AThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics.British journal of pharmacology · 2016Review
- Controlling murine and rat chronic pain through A3 adenosine receptor activation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed at comparing the binding characteristics of adenosine A(1) and A(2A) receptors (A(1)Rs and A(2A)Rs) in high-expressing cerebral areas, the cortex and striatum respectively, of human, bovine and rat brain. Adenosine A(3) receptor (A(3)R) binding was studied in rat and bovine testis. Results confirmed species differences in AR saturation-displacement binding parameters. To investigate A(3)Rs in CNS, we carried out immunoblot in human brain, resolving two signals, a 52 KDa band with the highest density in hippocampus and a 48 KDa one, slightly more expressed in cortex. Subsequently, A(3)R binding was performed by [(125)I]-4-aminobenzyl-5'-N-methylcarboxamidoadenosine ([(125)I]-AB-MECA) in human hippocampus, revealing an high affinity population of sites and another non saturable component. [(125)I]-AB-MECA first site displacement by N(6 )(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and 1,3-dipropyl-8-cyclopenthyl-xanthine (DPCPX) distinguished two affinity sites, being only in part identified as A(3)Rs. Therefore, A(3)Rs result clearly expressed by Western blot in human brain, but their full CNS characterization needs further investigation.
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