ArticlePloS one2007
PGC-1alpha inhibits oleic acid induced proliferation and migration of rat vascular smooth muscle cells.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases.Signal transduction and targeted therapy · 2024Review
- Effects of quercetin on hepatic fibroblast growth factor-21 (FGF-21) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) levels in rats fed with high fructose.Molecular biology reports · 2023Article
- Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoEDrug design, development and therapy · 2022Article
- Metabolomics reveals that CAF-derived lipids promote colorectal cancer peritoneal metastasis by enhancing membrane fluidity.International journal of biological sciences · 2022Article
- Comparison of trans-fatty acids on proliferation and migration of vascular smooth muscle cells.Food science and biotechnology · 2017Article
- Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content.BMC genomics · 2016Article
- Role of PGC-1α in Vascular Regulation: Implications for Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2016Review
- Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology.Seminars in immunopathology · 2014Review
- Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid.EMBO molecular medicine · 2013Article
- The retinol dehydrogenase Rdh10 localizes to lipid droplets during acyl ester biosynthesis.The Journal of biological chemistry · 2013Article
- Article
- Epicardial and subcutaneous adipose tissue Fatty acids profiles in diabetic and non-diabetic patients candidate for coronary artery bypass graft.BioImpacts : BI · 2013Article
- Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells.Genes & nutrition · 2012Article
- Effect of PGC-1α on proliferation, migration, and transdifferentiation of rat vascular smooth muscle cells induced by high glucose.Journal of biomedicine & biotechnology · 2012Article
- Oleic acid and adipokines synergize in inducing proliferation and inflammatory signalling in human vascular smooth muscle cells.Journal of cellular and molecular medicine · 2011Article
- PGC-1 coactivators in the control of energy metabolism.Acta biochimica et biophysica Sinica · 2011Review
- Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages.Molecular endocrinology (Baltimore, Md.) · 2009Article
- PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells.PloS one · 2009Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOleic acid (OA) stimulates vascular smooth muscle cell (VSMC) proliferation and migration. The precise mechanism is still unclear. We sought to investigate the effects of peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1 alpha (PGC-1alpha) on OA-induced VSMC proliferation and migration. PRINCIPAL
findingsOleate and palmitate, the most abundant monounsaturated fatty acid and saturated fatty acid in plasma, respectively, differently affect the mRNA and protein levels of PGC-1alpha in VSMCs. OA treatment resulted in a reduction of PGC-1alpha expression, which may be responsible for the increase in VSMC proliferation and migration caused by this fatty acid. In fact, overexpression of PGC-1alpha prevented OA-induced VSMC proliferation and migration while suppression of PGC-1alpha by siRNA enhanced the effects of OA. In contrast, palmitic acid (PA) treatment led to opposite effects. This saturated fatty acid induced PGC-1alpha expression and prevented OA-induced VSMC proliferation and migration. Mechanistic study demonstrated that the effects of PGC-1alpha on VSMC proliferation and migration result from its capacity to prevent ERK phosphorylation.
conclusionsOA and PA regulate PGC-1alpha expression in VSMCs differentially. OA stimulates VSMC proliferation and migration via suppression of PGC-1alpha expression while PA reverses the effects of OA by inducing PGC-1alpha expression. Upregulation of PGC-1alpha in VSMCs provides a potential novel strategy in preventing atherosclerosis.
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