Evidence map›Paper›PMID 17986455›Full record

ArticleNucleic acids research2008

UTRome.org: a platform for 3'UTR biology in C. elegans.

Marco Mangone, Philip Macmenamin, Charles Zegar, Fabio Piano, Kristin C Gunsalus

Abstract read
In one paragraph

Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. TheGenome research · 2019
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Gene-centered regulatory network mapping.Methods in cell biology · 2011
    Review
  13. Article
  14. The landscape of C. elegans 3'UTRs.Science (New York, N.Y.) · 2010
    Article
  15. Transgenic solutions for the germline.WormBook : the online review of C. elegans biology · 2010
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marco MangoneDepartment of Biology and Center for Genomics and Systems Biology, New York University, 100 Washington Square East, New York, NY 10003, USA.
Philip Macmenamin
Charles Zegar
Fabio Piano
Kristin C Gunsalus

Funding

Encyclopedia of C elegans 3'UTRS and their regulatory elementsU01HG004276 · NHGRI · NEW YORK UNIVERSITY · PI PIANO, FABIO · 2007 to 2011
$3.0M
Function and evolution of microRNAsR21HG003971 · NHGRI · NEW YORK UNIVERSITY · PI PIANO, FABIO · 2005 to 2006
$387k
NHGRI NIH HHS 1U01HG004276NHGRI NIH HHS R21 HG003971NHGRI NIH HHS R21HG003971NHGRI NIH HHS U01 HG004276
6 · The paper itself

Abstract

Three-prime untranslated regions (3'UTRs) are widely recognized as important post-transcriptional regulatory regions of mRNAs. RNA-binding proteins and small non-coding RNAs such as microRNAs (miRNAs) bind to functional elements within 3'UTRs to influence mRNA stability, translation and localization. These interactions play many important roles in development, metabolism and disease. However, even in the most well-annotated metazoan genomes, 3'UTRs and their functional elements are not well defined. Comprehensive and accurate genome-wide annotation of 3'UTRs and their functional elements is thus critical. We have developed an open-access database, available at http://www.UTRome.org, to provide a rich and comprehensive resource for 3'UTR biology in the well-characterized, experimentally tractable model system Caenorhabditis elegans. UTRome.org combines data from public repositories and a large-scale effort we are undertaking to characterize 3'UTRs and their functional elements in C. elegans, including 3'UTR sequences, graphical displays, predicted and validated functional elements, secondary structure predictions and detailed data from our cloning pipeline. UTRome.org will grow substantially over time to encompass individual 3'UTR isoforms for the majority of genes, new and revised functional elements, and in vivo data on 3'UTR function as they become available. The UTRome database thus represents a powerful tool to better understand the biology of 3'UTRs.

Indexed as

Databases, Nucleic Acid3' Untranslated RegionsAnimalsCaenorhabditis elegansInternetSoftwareUser-Computer Interface3' Untranslated Regions

Identifiers

PMID17986455
PMCPMC2238901

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.