ArticleTransgenic research2007
Biologically active human GM-CSF produced in the seeds of transgenic rice plants.
Article in Transgenic research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Plant Based Bioreactors of Recombinant Cytokines (Review).Applied biochemistry and microbiology · 2016Review
- Improving pharmaceutical protein production in Oryza sativa.International journal of molecular sciences · 2013Review
- 3D domain swapping causes extensive multimerisation of human interleukin-10 when expressed in planta.PloS one · 2012Article
- Recombinant cytokines from plants.International journal of molecular sciences · 2011Review
- Barley as a green factory for the production of functional Flt3 ligand.Biotechnology journal · 2010Article
- Plant-made vaccine antigens and biopharmaceuticals.Trends in plant science · 2009Review
- Subcutaneous Four-Week Repeated Dose Toxicity Studies of Rice Cell-Derived Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in Rats.Toxicological research · 2008Article
- Development and evaluation of transgenic rice seeds accumulating a type II-collagen tolerogenic peptide.Transgenic research · 2008Article
- Sustained expression of human cytomegalovirus glycoprotein B (UL55) in the seeds of homozygous rice plants.Molecular biotechnology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rice flour is a well-known and characterized source of pharmaceutical ingredients, which are gluten-free and incorporated in many drug delivery applications such as excipient starch. To further exploit this uniqueness, the synthetic capacity of rice endosperm tissue, the basis of rice flour, was extended by genetic transformation. Recombinant human GM-CSF, a cytokine used in treating neutropenia and with other potential clinical applications, has been expressed in transgenic rice seeds using a rice glutelin promoter. Rice seeds accumulated human GM-CSF to a level of 1.3% of total soluble protein. The rice seed-produced human GM-CSF was found to be biologically active when tested using a human cell line TF-1. Use of rice as a host plant offers not only attractive features of safe production in seeds but also self-containment of foreign genes, as rice is primarily a self-pollinated crop plant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.