ReviewClinical & experimental metastasis2007
Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms.
Review in Clinical & experimental metastasis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Predictive potential of hepatocyte growth factor and bone morphogenetic proteins in lymphatic metastasis of breast cancer.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025Article
- PAIP2 is a potential diagnostic and prognostic biomarker of breast cancer and is associated with immune infiltration.Frontiers in genetics · 2022Article
- Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis.International journal of molecular sciences · 2021Article
- Increased expression of miR-155 and miR-222 is associated with lymph node positive status.Journal of Cancer · 2018Article
- In Vivo Dual-Modality Fluorescence and Magnetic Resonance Imaging-Guided Lymph Node Mapping with Good Biocompatibility Manganese Oxide Nanoparticles.Molecules (Basel, Switzerland) · 2017Article
- The role of lymphangiogenesis and angiogenesis in tumor metastasis.Cellular oncology (Dordrecht, Netherlands) · 2016Review
- Lymphatic-targeted therapy following neoadjuvant chemotherapy: a promising strategy for lymph node-positive breast cancer treatment.Medical oncology (Northwood, London, England) · 2015Article
- [Detection of lymphovascular invasion in urothelial carcinoma of the bladder through D2-40 immunostaining].Der Urologe. Ausg. A · 2015Article
- Differential expression of miR-139, miR-486 and miR-21 in breast cancer patients sub-classified according to lymph node status.Cellular oncology (Dordrecht, Netherlands) · 2014Article
- Evaluation of the potential for lymph node metastasis using CRP 1846C>T genetic polymorphism in invasive breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- RNA-Seq and Network Analysis Revealed Interacting Pathways in TGF-β-Treated Lung Cancer Cell Lines.Cancer informatics · 2014Article
- Article
- CRSBP-1/LYVE-1 ligands disrupt lymphatic intercellular adhesion by inducing tyrosine phosphorylation and internalization of VE-cadherin.Journal of cell science · 2011Article
- Metastasis suppressor genes at the interface between the environment and tumor cell growth.International review of cell and molecular biology · 2011Review
- Angiogenesis-associated sequence variants relative to breast cancer recurrence and survival.Cancer causes & control : CCC · 2010Article
- Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression.European journal of human genetics : EJHG · 2010Article
- Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation.Oncogene · 2010Article
- Epigenetic contributions to cancer metastasis.Clinical & experimental metastasis · 2009Article
- BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours.British journal of cancer · 2008Article
- New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment.Clinical & experimental metastasis · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymph node metastasis is the main prognosis factor in a number of malignancies, including breast carcinomas. The means by which lymph node metastases arise is not fully understood, and many questions remain about their importance in the further spread of breast cancer. Nevertheless, a number of key cellular and molecular mechanisms of lymphatic metastasis have been identified. These include induction of intra- or peri-tumoral lymphangiogenesis or co-option of existing lymphatic vessels to allow tumour cells to enter the lymphatics, although it remains to be established whether this is primarily an active or passive process. Gene expression microarrays and functional studies in vitro and in vivo, together with detailed clinical observations have identified a number of molecules that can play a role in the genesis of lymph node metastases. These include the well-recognised lymphangiogenic cytokines VEGF-C and VEGF-D as well as chemokine-receptor interactions, integrins and downstream signalling pathways. This paper briefly reviews current clinical and experimental evidence for the underlying mechanisms and significance of lymphatic metastasis in breast cancer and highlights questions that still need to be addressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.