ArticlePediatric nephrology (Berlin, Germany)2008
Human immunodeficiency virus-associated nephropathy (HIVAN) in Nigerian children.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Prevalence of HIV-associated nephropathy in children: a systematic review with meta-analysis of studies published between 2004 and 2019.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- HIV-associated nephropathy in children: challenges in a resource-limited setting.Pediatric nephrology (Berlin, Germany) · 2023Review
- Correlation between CD4 count and glomerular filtration rate or urine protein:creatinine ratio in human immunodeficiency virus-infected children.Kidney research and clinical practice · 2020Article
- Kidney Disease in HIV Infection.Journal of clinical medicine · 2019Review
- Prevalence of risk factors for chronic kidney disease in South African youth with perinatally acquired HIV.Pediatric nephrology (Berlin, Germany) · 2019Article
- HIV-Associated Nephropathy in Africa: Pathology, Clinical Presentation and Strategy for Prevention.Journal of clinical medicine research · 2018Review
- Prevalence of Asymptomatic Microalbuminuria in HIV Positive Children in India.Indian journal of pediatrics · 2017Observational
- Renal abnormalities in a cohort of HIV-infected children and adolescents.Pediatric nephrology (Berlin, Germany) · 2016Article
- Renal abnormalities among HIV infected children at Muhimbili National Hospital (MNH)-Dar es Salaam, Tanzania.BMC nephrology · 2016Article
- Infection-Related Focal Segmental Glomerulosclerosis in Children.BioMed research international · 2016Review
- Renal transplantation in human immunodeficiency virus (HIV)-positive children.Pediatric nephrology (Berlin, Germany) · 2015Review
- HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment.Nature reviews. Nephrology · 2015Review
- Paediatric end-stage renal disease in a tertiary hospital in South West Nigeria.BMC nephrology · 2014Article
- Kidney disease in children and adolescents with perinatal HIV-1 infection.Journal of the International AIDS Society · 2013Review
- Renal manifestations of HIV infected highly active antiretroviral therapy naive children in India.World journal of pediatrics : WJP · 2012Article
- Recurrent thrombosis in an HIV-1 infected child.Indian journal of sexually transmitted diseases and AIDS · 2012Article
- The spectrum of HIV-related nephropathy in children.Pediatric nephrology (Berlin, Germany) · 2012Article
- Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria.International journal of nephrology · 2012Article
- Determining the prevalence of human immunodeficiency virus-associated nephropathy (HIVAN) using proteinuria and ultrasound findings in a Nigerian paediatric HIV population.The Pan African medical journal · 2012Article
- Nephrotic proteinuria and renal involvement in HIV-infected children.Indian journal of sexually transmitted diseases and AIDS · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human immunodeficiency virus-associated nephropathy (HIVAN) has rarely been reported in African children. In this single-center study, we analyzed ten children diagnosed with HIVAN from January 2000 to October 2006. There were eight boys and two girls, with a male:female ratio of 4:1. Their ages were from 5 months to 15 years (mean 6.8+/-6.2 years), with a peak age of 5-9 years. The presenting complaints included generalized edema (60%) and hypertension (50%). All patients had proteinuria on urine dipstick, with four (40%) at nephrotic range (proteinuria >or=500 mg/dl). Nine (90%) patients were in renal failure, with elevated serum creatinine (6.3-24 mg/dl) and serum urea (70-120 mg/dl). Renal disease was the first manifestation of HIV infection in six patients, whereas the diagnosis was made on autopsy in three. The duration from HIV infection to development of HIVAN ranged from 5 months to 10 years. CD4(+) cell count, done in only three patients due to financial constraints, was below 200/mm(3). The kidneys were hyperechoic on abdominal ultrasound in all patients, and three (30%) showed grossly enlarged kidneys. Histology of renal tissues available by autopsy in three patients showed mainly collapsing focal segmental glomerulosclerosis. Treatments given were angiotensin-converting enzyme (ACE) inhibitors and highly active antiretroviral therapy (HAART) in four and two patients, respectively, and one patient underwent peritoneal dialysis. On outcome analysis, seven (70%) patients died, two were lost to follow-up, and one was alive on HAART therapy at the writing of this article. In conclusion, HIVAN occurs in Nigeria children, and the mortality is very high from uremia.
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