ReviewProstate cancer and prostatic diseases2008
Prostate cell cultures as in vitro models for the study of normal stem cells and cancer stem cells.
Review in Prostate cancer and prostatic diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- Physiological elasticity and topography modulateiScience · 2026Article
- Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies.Frontiers in oncology · 2022Review
- Regulating Stem Cell-Related Genes Induces the Plastic Differentiation of Cancer Stem Cells to Treat Breast Cancer.Molecular therapy oncolytics · 2020Article
- MDA-9/Syntenin (SDCBP) Is a Critical Regulator of Chemoresistance, Survival and Stemness in Prostate Cancer Stem Cells.Cancers · 2019Article
- Efficient and simple approach to in vitro culture of primary epithelial cancer cells.Bioscience reports · 2016Article
- s-SHIP expression identifies a subset of murine basal prostate cells as neonatal stem cells.Oncotarget · 2016Article
- Notch signaling in the prostate: critical roles during development and in the hallmarks of prostate cancer biology.Journal of cancer research and clinical oncology · 2016Review
- Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.Oncotarget · 2016Article
- Effects of oxygen on the antigenic landscape of prostate cancer cells.BMC research notes · 2015Article
- Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19.Stem cells and development · 2015Article
- Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin.Stem cell reports · 2015Article
- Dependence of castration-resistant prostate cancer (CRPC) stem cells on CRPC-associated fibroblasts.Journal of cellular physiology · 2014Article
- Expression profiling of stem cell signaling alters with spheroid formation in CD133Oncology letters · 2014Article
- The CD44(high) tumorigenic subsets in lung cancer biospecimens are enriched for low miR-34a expression.PloS one · 2013Article
- α-blockade, apoptosis, and prostate shrinkage: how are they related?Central European journal of urology · 2013Review
- Actions of estrogens and endocrine disrupting chemicals on human prostate stem/progenitor cells and prostate cancer risk.Molecular and cellular endocrinology · 2012Review
- Prostate cancer stem cell biology.Minerva urologica e nefrologica = The Italian journal of urology and nephrology · 2012Review
- ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells.The American journal of pathology · 2012Article
- Emerging putative biomarkers: the role of alpha 2 and 6 integrins in susceptibility, treatment, and prognosis.Prostate cancer · 2012Article
- Side population rather than CD133(+) cells distinguishes enriched tumorigenicity in hTERT-immortalized primary prostate cancer cells.Molecular cancer · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current existing therapies for prostate cancer eradicate the majority of cells within a tumor. However, most patients with advanced cancer still progress to androgen-independent metastatic disease that remains essentially incurable by current treatment strategies. Recent evidence has shown that cancer stem cells (CSCs) are a subset of the tumor cells that are responsible for initiating and maintaining the disease. Understanding normal stem cells and CSCs may provide insight into the origin of and new therapeutics for prostate cancer. Normal stem cells and CSCs have been identified in prostate tissue by the use of several markers or techniques. Although research on stem cells has been limited by the lack of suitable in vitro systems, recent studies show that not only primary cells but also several established cell lines may exhibit stem cell properties. This review discusses various in vitro culture systems to propagate normal prostate stem cells and prostate CSCs together with molecular markers. These in vitro cell culture models should be useful for elucidating the differentiation of prostatic epithelium and the biological features of prostate cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.